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In the liver, injury is promoted by immune effector mechanisms that are common across various disease etiologies and even between organs such as lungs, kidneys, heart, and other organs. Thus, the liver represents a useful model to study inflammation and repair, particularly as it is frequently biopsied in clinical contexts. Currently, strong evidence implicates\n                    <jats:italic toggle=\"yes\">IFNL3\/4<\/jats:italic>\n                    polymorphisms and interferon (IFN)-\u03bb3 levels as determinants of the extent of hepatic inflammation and fibrosis in viral and nonviral liver diseases, as well as in governing the severity of nonhepatotropic viral diseases. Interestingly,\n                    <jats:italic toggle=\"yes\">IFNL3\/4<\/jats:italic>\n                    polymorphisms and IFN-\u03bb3 levels correlate with fibrosis extent in other organs such as the lung and kidney. In this review, we discuss the association between IFN-\u03bb and tissue inflammation and fibrosis in human disease and the potential clinical utility of the findings.\n                  <\/jats:p>","DOI":"10.1089\/jir.2018.0175","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T14:33:37Z","timestamp":1556030017000},"page":"627-635","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Interferon Lambda and Liver Fibrosis"],"prefix":"10.1177","volume":"39","author":[{"given":"Mohammed","family":"Eslam","sequence":"first","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golo","family":"Ahlenstiel","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, Australia."},{"name":"Blacktown Medical School, Western Sydney University, Blacktown, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"crossref","first-page":"S449","DOI":"10.1016\/S0168-8278(10)61165-8","article-title":"Common variation of Il28 affects gamma-Gtp levels and inflammation of the liver in chronically hepatitis C virus infected patients","volume":"52","author":"Abe H","year":"2010","unstructured":"Abe H, , Hayes CN, , Ochi H, , Maekawa T, , Tsuge M, , Miki D, , Mitsui F, , Hiraga N, , Imamura M, , Takahashi S, , Chayama K. 2010. 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