{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:06:47Z","timestamp":1777702007001,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Interleukin (IL)-35 is confirmed as an important modulator in immune response. The aim of the study was to explore the role of IL-35 in the development of polymyositis\/dermatomyositis (PM\/DM). Ninety-five patients with PM\/DM and 30 healthy controls (HCs) were recruited. Peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll-Paque Plus density gradient centrifugation. Protein IL-35, IL-17, and tumor necrosis factor (TNF)-\u03b1 levels were measured using enzyme-linked immunosorbent assay method. The IL-35 serum levels in PM\/DM patients were significantly higher than those in HCs and were correlated with PM\/DM-related features: disease activity, muscle damage, and interstitial lung disease (ILD). Exogenous IL-35 notably suppressed lipopolysaccharide-induced IL-17 and TNF-\u03b1 production in PBMCs of patients with PM\/DM. Elevated serum IL-35 levels could act as a disease activity biomarker and an indicator of ILD in PM\/DM. IL-35 may play an anti-inflammatory role in PM\/DM.<\/jats:p>","DOI":"10.1089\/jir.2019.0063","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T09:55:32Z","timestamp":1562320532000},"page":"720-725","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Interleukin-35: A Serological Biomarker for Patients with Polymyositis\/Dermatomyositis"],"prefix":"10.1177","volume":"39","author":[{"given":"Qinglai","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, the First Affiliated Hospital of China Medical University, Shenyang, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, the First Affiliated Hospital of China Medical University, Shenyang, P.R. 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