{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:52:13Z","timestamp":1780505533316,"version":"3.54.1"},"reference-count":57,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>\n                    Multiple myeloma (MM) remains an intractable hematological malignancy, despite recent advances in anti-MM drugs. Here, we show that role of PDZ binding kinase (PBK) in MM tumor growth. We identified that interleukin-6 (IL-6) readily increases PBK expression. Kaplan\u2013Meier analysis showed that the MM patients with higher expression of PBK have a significant shorter survival time compared with those with moderate\/lower expression of PBK. Knockout of\n                    <jats:italic toggle=\"yes\">PBK<\/jats:italic>\n                    dramatically suppressed\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    tumor growth in MM cells, while genome editing of\n                    <jats:italic toggle=\"yes\">PBK<\/jats:italic>\n                    changing from asparagine to serine substitution (rs3779620) slightly suppresses the tumor formation. Mechanistically, loss of\n                    <jats:italic toggle=\"yes\">PBK<\/jats:italic>\n                    increased the number of apoptotic cells with concomitant decrease in the phosphorylation level of Stat3 as well as caspase activities. A novel PBK inhibitor OTS514 significantly decreased KMS-11-derived tumor growth. These findings highlight the novel oncogenic role of PBK in tumor growth of myeloma, and it might be a novel therapeutic target for the treatment of patients with MM.\n                  <\/jats:p>","DOI":"10.1089\/jir.2020.0111","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T17:56:16Z","timestamp":1595958976000},"page":"389-405","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells"],"prefix":"10.1177","volume":"40","author":[{"given":"Akinobu","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Hanamura","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivasundaram","family":"Karnan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Inaguma","sequence":"additional","affiliation":[{"name":"Department of Pathology, Aichi Medical University School of Medicine, Nagakute, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Takei","sequence":"additional","affiliation":[{"name":"Institute for Animal Experimentation, Faculty of Medicine, Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Quang","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Aichi Medical University 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