{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T01:07:12Z","timestamp":1782349632183,"version":"3.54.5"},"reference-count":53,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    There remains a dearth of data regarding the association between chronic inflammation and hypertension (HTN) in sub-Saharan Africa, a region that accounts for &gt;70% of the global burden of HIV infection. Therefore, we assessed the levels of biomarkers among HIV+ individuals and its associations with HTN in Tanzania. A cross-sectional study was conducted at one of the largest clinics in Tanzania and data from 261 HIV+ patients were analyzed. Standardized tools were used to collect data. Blood pressure was measured using Omron\n                    <jats:sup>\u00ae<\/jats:sup>\n                    M2 blood pressure monitor. Enzyme-linked immunosorbent assay was used to test for inflammatory markers [C-reactive protein (CRP), interleukin (IL)-6, IL-18, soluble tumor necrosis factor receptor type I (sTNFRI), sTNFRII]. Bivariate and multivariable analysis was conducted to examine association between the biomarkers and HTN. We further conducted age\u2013sex\u2013alcohol-adjusted models to control for any confounders. The prevalence of HTN was 43% with a high prevalence reported in female (70%) participants and those older than 55 years of age (77%). Being women, older than 55 years of age, married, and being overweight was associated with HTN. The highest correlations were observed between TNR2 and CRP (\u0264\u2009=\u20090.13,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.044), and TNR2 and IL-18 (\u0264\u2009=\u20090.13,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.034). Participants who had elevated CRP levels were 2 times more likely to experience HTN in the age-adjusted model [odds ratio (OR)\u2009=\u20093.5, 95% confidence interval (CI)\u2009=\u20091.1\u201311.3], age\u2013sex-adjusted model (OR\u2009=\u20093.3, 95% CI\u2009=\u20091.0\u201310.9), and the full model (OR\u2009=\u20092.9, 95% CI\u2009=\u20090.8\u201310.0). Our study shows that high CRP levels are significantly associated with the higher prevalence of HTN notwithstanding all other markers, which showed a positive association with HTN despite not being significant. These findings point to the importance of creating awareness, education, and screening for HTN among HIV patients in high epidemic countries. More rigorous studies are needed to know the exact pathway mechanisms of inflammation in HIV patients.\n                  <\/jats:p>","DOI":"10.1089\/jir.2021.0059","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T13:48:06Z","timestamp":1629380886000},"page":"291-301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Hypertension and Associated Inflammatory Markers Among HIV-Infected Patients in Tanzania"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-188X","authenticated-orcid":false,"given":"Peter","family":"Memiah","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Prevention, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Nkinda","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mtebe","family":"Majigo","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Opanga","sequence":"additional","affiliation":[{"name":"Department of Monitoring Evaluation and Research, Amref Health Africa, Nairobi, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Humwa","sequence":"additional","affiliation":[{"name":"Global Program for Research Teaching\u2014University of California San Francisco, Nairobi, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Inzaule","sequence":"additional","affiliation":[{"name":"Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maghimbi","family":"Abubakar","sequence":"additional","affiliation":[{"name":"Center for International Health, Education, and Biosecurity (CIHEB), Institute of Human Virology, University of Maryland School of Medicine in Tanzania, Dar es Salaam, Tanzania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patience","family":"Oduor","sequence":"additional","affiliation":[{"name":"Center for International Health, Education, and Biosecurity (CIHEB), Institute of Human Virology, University of Maryland School of Medicine in Tanzania, Dar es Salaam, Tanzania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Zuheri","sequence":"additional","affiliation":[{"name":"Infectious Disease Centre, Tanzania, Dar es Salaam, Tanzania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lema","sequence":"additional","affiliation":[{"name":"Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kamau","sequence":"additional","affiliation":[{"name":"Institute for Development Studies, University of Nairobi, Nairobi, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyprien","family":"Baribwira","sequence":"additional","affiliation":[{"name":"PUniversity of Maryland School of Medicine in Rwanda, Kigali, Rwanda."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibhatu","family":"Biadgilign","sequence":"additional","affiliation":[{"name":"Public Health Research Consultant, Addis Ababa, Ethiopia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"e_1_3_6_2_1","first-page":"953463","article-title":"Cardiovascular inflammation 2012: Reactive oxygen species, SUMOylation, and biomarkers in cardiovascular inflammation","volume":"2013","author":"Abe JI","year":"2013","unstructured":"Abe JI, , Manabe I, , Aikawa M, , Aikawa E. 2013. Cardiovascular inflammation 2012: Reactive oxygen species, SUMOylation, and biomarkers in cardiovascular inflammation. Int J Inflam, 2013:953463.","journal-title":"Int J Inflam"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.093336"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/182575"},{"key":"e_1_3_6_5_1","unstructured":"American Heart Association. 2016. 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The burden of hypertension in sub-Saharan Africa: a four-country cross sectional study. 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