{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:27:12Z","timestamp":1783016832607,"version":"3.54.6"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2022,4,1]]},"DOI":"10.1089\/jir.2021.0206","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T11:21:17Z","timestamp":1649244077000},"page":"153-160","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Rapamycin on MOG-Reactive Immune Cells and Lipopolysaccharide-Activated Microglia: An\n                    <i>In Vitro<\/i>\n                    Approach for Screening New Therapies for Multiple Sclerosis"],"prefix":"10.1177","volume":"42","author":[{"given":"Patricia Aparecida","family":"Borim","sequence":"first","affiliation":[{"name":"Graduate Program in Tropical Diseases, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Ayumi Nishiyama","family":"Mimura","sequence":"additional","affiliation":[{"name":"Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Fernanda Gon\u00e7alves","family":"Zorzella-Pezavento","sequence":"additional","affiliation":[{"name":"Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Manganeli","family":"Polonio","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, University of S\u00e3o Paulo (ICB IV\/USP), S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Pierre Schatzmann","family":"Peron","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, University of S\u00e3o Paulo (ICB IV\/USP), S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandrina","family":"Sartori","sequence":"additional","affiliation":[{"name":"Graduate Program in Tropical Diseases, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil."},{"name":"Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2053-8938","authenticated-orcid":false,"given":"Thais Fernanda de Campos","family":"Fraga-Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Tropical Diseases, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00753"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.08.009"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy131"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2005"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5732"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103119"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.7.8044"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11080443"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-017-2296-7"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23760"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"issue":"2","key":"B12","first-page":"46","volume":"252","author":"Kappos L","year":"2005","journal-title":"J Neurol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2019.52.10.026"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600495R"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.001"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.590884"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.04.035"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201743922"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.959"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636837"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030598"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144987"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.245964"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.1.1.57"},{"issue":"2","key":"B25","first-page":"141","volume":"13","author":"Salehi M","year":"2016","journal-title":"Iranian J Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1762-z"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701477"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.05.012"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.023"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/nri3901"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117747"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27792"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649502"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14042"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.05.002"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2014.09.004"}],"container-title":["Journal of Interferon &amp; Cytokine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/jir.2021.0206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/jir.2021.0206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:35:53Z","timestamp":1777455353000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/jir.2021.0206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4,1]]}},"alternative-id":["10.1089\/jir.2021.0206"],"URL":"https:\/\/doi.org\/10.1089\/jir.2021.0206","relation":{},"ISSN":["1079-9907","1557-7465"],"issn-type":[{"value":"1079-9907","type":"print"},{"value":"1557-7465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,1]]}}}