{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:09:54Z","timestamp":1787008194161,"version":"build-2736575974"},"reference-count":51,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>\n                    Interferon-induced transmembrane (IFITM) proteins mediate protection against enveloped viruses by blocking membrane fusion at endosomes. IFITM1 and IFITM3 are crucial for protection against influenza, and various single nucleotide polymorphisms altering their function have been linked to disease susceptibility. However, bulk\n                    <jats:italic toggle=\"yes\">IFITM1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">IFITM3<\/jats:italic>\n                    mRNA expression dynamics and their correlation with clinical outcomes have not been extensively addressed in patients with respiratory infections. In this study, we evaluated the expression of\n                    <jats:italic toggle=\"yes\">IFITM1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">IFITM3<\/jats:italic>\n                    in peripheral leukocytes from healthy controls and individuals with severe pandemic influenza A(H1N1) or coronavirus disease 2019 (COVID-19). Comparisons between participants grouped according to their clinical characteristics, underlying disease, and outcomes showed that the downregulation of\n                    <jats:italic toggle=\"yes\">IFITM1<\/jats:italic>\n                    was a distinctive characteristic of severe pandemic influenza A(H1N1) that correlated with outcomes, including mortality. Conversely, increased\n                    <jats:italic toggle=\"yes\">IFITM3<\/jats:italic>\n                    expression was a common feature of severe pandemic influenza A(H1N1) and COVID-19. Using a high-dose murine model of infection, we confirmed not only the downregulation of\n                    <jats:italic toggle=\"yes\">IFITM1<\/jats:italic>\n                    but also of\n                    <jats:italic toggle=\"yes\">IFITM3<\/jats:italic>\n                    in the lungs of mice with severe influenza, as opposed to humans. Analyses in the comparative cohort also indicate the possible participation of IFITM3 in COVID-19. Our results add to the evidence supporting a protective function of IFITM proteins against viral respiratory infections in humans.\n                  <\/jats:p>","DOI":"10.1089\/jir.2022.0036","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T10:52:16Z","timestamp":1655376736000},"page":"430-443","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Differential Leukocyte Expression of\n                    <i>IFITM1<\/i>\n                    and\n                    <i>IFITM3<\/i>\n                    in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19"],"prefix":"10.1177","volume":"42","author":[{"given":"Nora E.","family":"Regino-Zamarripa","sequence":"first","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."},{"name":"Programa de Doctorado en Ciencias Quimicobiol\u00f3gicas, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prolongaci\u00f3n de Carpio and Plan de Ayala s\/n, Mexico City, Mexico."},{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5157-0677","authenticated-orcid":false,"given":"Gustavo","family":"Ram\u00edrez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Armando","family":"Jim\u00e9nez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Cruz-Lagunas","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzel Alejandra","family":"G\u00f3mez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."},{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Ignacio-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."},{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eduardo","family":"M\u00e1rquez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette Miroslava","family":"Pacheco-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."},{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jazm\u00edn Ariadna","family":"Ram\u00edrez-Noyola","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."},{"name":"Programa de Maestr\u00eda en Ciencias de la Salud, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Salvador D\u00edaz Mir\u00f3n and Plan de San Luis, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Barquera","sequence":"additional","affiliation":[{"name":"Department of Archaeogenetics, Max Planck Institute for Science of Human History, Jena, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Criselda","family":"Mendoza-Milla","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."},{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Luna-Rivero","sequence":"additional","affiliation":[{"name":"Deparment of Pathology, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Guillermo","family":"Dom\u00ednguez-Cherit","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico."},{"name":"Critical Care Unit, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remedios","family":"Ram\u00edrez-Rangel","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Investigaci\u00f3n Cient\u00edfica, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Sof\u00eda","family":"Rodr\u00edguez-Reyna","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen M.","family":"Hern\u00e1ndez-C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Respiratory Critical Care Unit, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas,\u201d Mexico City, 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Swine influenza A (H1N1) infection in two children\u2014Southern California, March-April 2009. MMWR Morb Mortal Wkly Rep, 58(15):400\u2013402.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034508"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744100"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.593595"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5517856"},{"key":"e_1_3_6_12_1","first-page":"21","article-title":"Expression of Surfactant protein D (SP-D) distinguishes severe pandemic influenza A(H1N1) from COVID-19","volume":"224","author":"Chore\u00f1o-Parra JA","year":"2021","unstructured":"Chore\u00f1o-Parra JA, , Jim\u00e9nez-\u00c1lvarez LA, , Ram\u00edrez-Mart\u00ednez G, , Cruz-Lagunas A, , Thapa M, , Fern\u00e1ndez-L\u00f3pez LA, , Carnalla-Cort\u00e9s M, , Chore\u00f1o-Parra EM, , Mena-Hern\u00e1ndez L, , Sandoval-Vega M, , Hern\u00e1ndez-Montiel EM, , Hern\u00e1ndez-Garc\u00eda DL, , Ram\u00edrez-Noyola JA, , Reyes-L\u00f3pez CE, , Dom\u00ednguez-Faure A, , Zamudio-L\u00f3pez GY, , M\u00e1rquez-Garc\u00eda E, , Moncada-Morales A, , Mendoza-Milla C, , Cerv\u00e1ntes-Rosete D, , Mu\u00f1oz-Torrico M, , Luna-Rivero C, , Garc\u00eda-Latorre EA, , Guadarrama-Ort\u00edz P, , \u00c1vila-Moreno F, , Dom\u00ednguez-Cherit G, , Rodr\u00edguez-Reyna TS, , Mudd PA, , Hern\u00e1ndez-C\u00e1rdenas CM, , Khader SA, , Z\u00fa\u00f1iga J. 2021c. Expression of Surfactant protein D (SP-D) distinguishes severe pandemic influenza A(H1N1) from COVID-19. 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