{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:57:25Z","timestamp":1778561845189,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    Hypertrophic scar (HS) is a severe skin fibrotic disorder with unclear pathogenesis. Interferon-\u03b12b (IFN-\u03b12b) exerts inhibitory effects on HS\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    ; however, the exact mechanism remains unclear. In this study, we aimed to evaluate the inhibitory effects of IFN-\u03b12b on hypertrophic scar fibroblasts' (HSFs) proliferation and migration, and to further investigate the associated molecular mechanism. Cell Counting Kit-8 and CyQUANT assays were used to assess HSFs' proliferation; wound healing and Transwell assays were used to assess HSFs' migration; real-time quantitative polymerase chain reaction and Western blotting were used to detect messenger RNA and protein levels, respectively, of related genes; bioinformatics analysis was performed to predict the downstream target of IFN-\u03b12b. Our findings are as follows: (1) IFN-\u03b12b inhibited HSFs' proliferation and migration in a dose-dependent manner. (2) IFN-\u03b12b inhibited HSFs' proliferation and migration by suppressing the Wnt\/\u03b2-catenin pathway. (3) Retinoic-acid receptor responder 3 (RARRES3) was predicted as a functional downstream molecule of IFN-\u03b12b, which was low in HSFs. (4) IFN-\u03b12b inhibited HSF phenotypes and the Wnt\/\u03b2-catenin pathway by upregulating RARRES3 expression. (5) RARRES3 restrained HSFs' proliferation and migration by repressing the Wnt\/\u03b2-catenin pathway. In conclusion, IFN-\u03b12b-induced RARRES3 upregulation inhibited HSFs' proliferation and migration through Wnt\/\u03b2-catenin pathway suppression.\n                  <\/jats:p>","DOI":"10.1089\/jir.2022.0183","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T12:24:33Z","timestamp":1671107073000},"page":"23-34","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Interferon-\u03b12b-Induced RARRES3 Upregulation Inhibits Hypertrophic Scar Fibroblasts' Proliferation and Migration Through Wnt\/\u03b2-Catenin Pathway Suppression"],"prefix":"10.1177","volume":"43","author":[{"given":"Xianglong","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Burns Surgery, The First Hospital of Jilin University, Changchun, China."},{"name":"Jilin Provincial Skin Repair and Regeneration Engineering Research Center, Jilin University, Changchun, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Burns Surgery, The First Hospital of Jilin University, Changchun, China."},{"name":"Jilin Provincial Skin Repair and Regeneration Engineering Research Center, Jilin University, Changchun, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Burns Surgery, The First Hospital of Jilin University, Changchun, China."},{"name":"Jilin Provincial Skin Repair and Regeneration Engineering Research Center, Jilin University, Changchun, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingchun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Burns Surgery, The First Hospital of Jilin University, Changchun, China."},{"name":"Jilin Provincial Skin Repair and Regeneration Engineering Research Center, Jilin University, Changchun, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burns Surgery, The First Hospital of Jilin University, Changchun, China."},{"name":"Jilin Provincial Skin Repair and Regeneration Engineering Research Center, Jilin University, Changchun, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Burns Surgery, The First Hospital of Jilin University, Changchun, China."},{"name":"Jilin Provincial Skin Repair and Regeneration Engineering Research Center, Jilin University, Changchun, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2184-040X","authenticated-orcid":false,"given":"Xianjun","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Engineering, Jilin Engineering Normal University, Changchun, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Burns Surgery, The First Hospital of Jilin University, Changchun, China."},{"name":"Jilin Provincial Skin Repair and Regeneration Engineering Research Center, Jilin University, Changchun, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.07.017"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn764"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.08.001"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14811"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4227"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)31406-4"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220098110"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.175"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13765-021-00641-2"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.04.017"},{"key":"e_1_3_5_13_1","unstructured":"Oliveros JC. 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