{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:47:12Z","timestamp":1777700832207,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>\n                    Globally, \u223c56.8 million people are chronically infected with hepatitis C virus (HCV), with about half residing in Asia. The cost and efficiency of delivering regimens based on direct-acting antiviral agents for HCV are important considerations in implementing these curative treatments. For sofosbuvir-based regimens, most patients are treated for 12 weeks; however, treatment for 8 weeks has been shown to cure HCV infection in 95% of patients without cirrhosis. Furthermore, virological failure after 8-week treatment occurs in only 1%\u20132% of individuals without cirrhosis, who have a favorable\n                    <jats:italic toggle=\"yes\">IFNL4<\/jats:italic>\n                    genotype, which is present in &gt;50% of South Asians and &gt;80% of East Asians. We propose that sofosbuvir-based treatment for 8 weeks, or perhaps shorter, would yield high response rate regimens in Asian countries and markedly increase the number of patients who could be cured for a given cost of the medication. We propose that a noninferiority trial in an East Asian population be conducted to test this hypothesis.\n                  <\/jats:p>","DOI":"10.1089\/jir.2023.0022","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T23:04:54Z","timestamp":1687475094000},"page":"435-438","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>IFNL4<\/i>\n                    Genotype Frequencies in Asian Populations Support Shorter Duration Therapy with Sofosbuvir-Based Hepatitis C Virus Regimens to Increase the Number Cured"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0003-6065","authenticated-orcid":false,"given":"Thomas R.","family":"O'Brien","sequence":"first","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Hsuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Kottilil","sequence":"additional","affiliation":[{"name":"Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit433"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613512"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183084"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.047"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004681"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402355"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(15)30012-X"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit827"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.453"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28292"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.069"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofu110"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.035"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2521"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.447"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.449"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00346-6"}],"container-title":["Journal of Interferon &amp; Cytokine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jir.2023.0022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2023.0022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2023.0022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:31:29Z","timestamp":1777455089000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jir.2023.0022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1089\/jir.2023.0022"],"URL":"https:\/\/doi.org\/10.1089\/jir.2023.0022","relation":{},"ISSN":["1079-9907","1557-7465"],"issn-type":[{"value":"1079-9907","type":"print"},{"value":"1557-7465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]}}}