{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:49:49Z","timestamp":1777700989579,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Cytokines are crucial in controlling inflammation during viral infection, particularly infection with the hepatitis C virus (HCV). Cytokine genetic polymorphisms can change how the immune system responds to this infection. We investigated how the HCV infection treatment was affected by single nucleotide polymorphisms in these genes. The goal of this study was to examine any connections between the cytokine gene polymorphisms for interleukins (IL)-22-binding protein rs6570136, as well as IL-10 rs1800872 and rs1878672 in the Pakistani population and responsiveness to direct-acting antivirals (DAAs) treatment. This study evaluated 155 participants, which included 55 patients who achieved sustained virologic response (SVR), 40 relapse patients, and 60 healthy controls, to assess and compare the clinical parameters. The SVR and relapse groups were compared for their allelic and genotypic frequencies. We discovered that the SVR and the relapse groups had significantly different genotype frequencies for IL-10 rs1800872 and IL-22BP rs6570136 in the Pakistani population. The G\/G genotype in rs6570136 and A\/A genotype in rs1800872 were significantly associated with relapse following DAA therapy, with\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    values 0.002 and 0.0004, respectively. In contrast, rs1878672 showed no significant correlation with HCV relapse,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.63.\n                  <\/jats:p>","DOI":"10.1089\/jir.2025.0005","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T12:26:36Z","timestamp":1742387196000},"page":"196-204","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polymorphisms in IL-10- and IL-22-Binding Protein Genes as Genetic Predictors of the Direct-Acting Antivirals Treatment Response in Patients with Chronic Hepatitis C Virus"],"prefix":"10.1177","volume":"45","author":[{"given":"Komal","family":"Saleem","sequence":"first","affiliation":[{"name":"National Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hira Raheem","family":"Akbar","sequence":"additional","affiliation":[{"name":"National Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana Macek","family":"Jilkova","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, University Grenoble Alpes, CNRS UMR5309, INSERM U1209, 38700 Grenoble, France."},{"name":"Hepato-Gastroenterology and Digestive Oncology Department, CHU Grenoble Alpes, 38700 Grenoble, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Ali","family":"Shahid","sequence":"additional","affiliation":[{"name":"National Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Idrees","sequence":"additional","affiliation":[{"name":"National Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-5735","authenticated-orcid":false,"given":"Samia","family":"Afzal","sequence":"additional","affiliation":[{"name":"National Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.034"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00628"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.03.027"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i16.1691"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.1061"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155784"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/03946320241240705"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057246"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15546"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/2314808X.2023.2254508"},{"issue":"2","key":"e_1_3_3_12_1","first-page":"589","article-title":"Comparative study between responders and non responders among patients treated for Hepatitis C virus infection","volume":"39","author":"Elhammadi A","year":"2022","unstructured":"Elhammadi A, , Ziada D, , Farrag W. Comparative study between responders and non responders among patients treated for Hepatitis C virus infection. Benha Medical Journal, 2022; 39(2):589\u2013601.","journal-title":"Benha Medical Journal"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021380"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246019"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu016"},{"issue":"4","key":"e_1_3_3_16_1","first-page":"512","article-title":"Association of IL28 B and IL10 Polymorphism with HCV infection and direct antiviral treatment","volume":"51","author":"Junaid K","year":"2021","unstructured":"Junaid K, , Rasool H, , Ul Mustafa A, et al. Association of IL28 B and IL10 Polymorphism with HCV infection and direct antiviral treatment. Ann Clin Lab Sci, 2021; 51(4):512\u2013520.","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814000466"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/livers1040024"},{"key":"e_1_3_3_19_1","doi-asserted-by":"crossref","unstructured":"Manns MP Buti M Gane E et al. Hepatitis C virus infection. 2017; 3(1):1\u201319.","DOI":"10.1038\/nrdp.2017.6"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2020.1746641"},{"issue":"2","key":"e_1_3_3_21_1","first-page":"2039","article-title":"Study of physiological and some biochemical parameters in patients infected with chronic Hepatitis-B virus","volume":"22","author":"Mohammed HK","year":"2022","unstructured":"Mohammed HK. Study of physiological and some biochemical parameters in patients infected with chronic Hepatitis-B virus. HIV Nursing, 2022; 22(2):2039\u20132044.","journal-title":"HIV Nursing"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.21608\/mjvh.2022.279334"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-018-3711-3"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(00)70134-x"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-015-2493-0"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojgas.2020.1011027"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.09.011"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27629"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.10.004"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.03.007"},{"issue":"1","key":"e_1_3_3_31_1","first-page":"161","article-title":"Serum Al-pha-Fetoprotein, albumin and previous antiviral treatment, can predict non-response to direct antiviral therapy in Egyp-tian patients with chronic Hepatitis-C","volume":"5","author":"Shousha H","year":"2021","unstructured":"Shousha H, , Saad Y, , Saleh D. 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