{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:01:42Z","timestamp":1789387302109,"version":"build-2803163510"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>\n                    Our previous study showed that the methanolic extract of\n                    <jats:italic toggle=\"yes\">Inula helenium<\/jats:italic>\n                    (elecampane) had the potential to induce detoxifying enzymes such as quinine reductase (QR) and glutathione\n                    <jats:italic toggle=\"yes\">S<\/jats:italic>\n                    -transferase. In this study we further fractionated the methanolic extract into hexane-, dichloromethane-, butanol-, and water-soluble fractions according to polarity. The hexane fraction showed the highest QR-inducing activity and also induced glutathione\n                    <jats:italic toggle=\"yes\">S<\/jats:italic>\n                    -transferase in a dose-dependent manner. Its potential to induce the reporter activity suggested an antioxidant response element-mediated mechanism of action in the induction of phase II detoxifying enzymes. Intraperitoneal injection of the hexane fraction of\n                    <jats:italic toggle=\"yes\">I. helenium<\/jats:italic>\n                    into ICR mice caused a significant increase of QR activity in liver, kidney, small intestine, and stomach. Sesquiterpenes, isolated from the hexane fraction, appeared to be major components responsible for QR induction. Among the seven compounds tested in this study, alantolactone, isoalantolactone, and 5\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    -epoxyalantolactone significantly induced QR activity in both Hepa1c1c7 and BPRc1 cells. In conclusion, sesquiterpenes, including alantolactone, isoalantolactone and 5-epoxyalantolactone, present in\n                    <jats:italic toggle=\"yes\">I. helenium<\/jats:italic>\n                    merit further evaluation as chemopreventive agents.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2006.209","type":"journal-article","created":{"date-parts":[[2007,7,26]],"date-time":"2007-07-26T07:06:23Z","timestamp":1185433583000},"page":"503-510","source":"Crossref","is-referenced-by-count":35,"title":["Induction of Detoxifying Enzyme by Sesquiterpenes Present in\n                    <i>Inula helenium<\/i>"],"prefix":"10.1177","volume":"10","author":[{"given":"Soon Sung","family":"Lim","sequence":"first","affiliation":[{"name":"Regional Innovation Center and Department of Food Science and Nutrition, Hallym University, Chuncheon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Ryoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Kyungpook National University, Daegu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ae","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Kyungpook National University, Daegu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Ho","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Kyungpook National University, Daegu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Kyoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Forest Products, Kookmin University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Konishi","sequence":"additional","affiliation":[{"name":"Kyoto Pharmaceutical University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Regional Innovation Center and Department of Food Science and Nutrition, Hallym University, Chuncheon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Han Yoon","family":"Park","sequence":"additional","affiliation":[{"name":"Regional Innovation Center and Department of Food Science and Nutrition, Hallym University, Chuncheon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Sang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Kyungpook National University, Daegu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,9,1]]},"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2006.209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2006.209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:13:04Z","timestamp":1777644784000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2006.209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1089\/jmf.2006.209"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2006.209","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}