{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:29:10Z","timestamp":1791253750900,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>\n                    Commercial coenzyme Q\n                    <jats:sub>10<\/jats:sub>\n                    (CoQ\n                    <jats:sub>10<\/jats:sub>\n                    ) and\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    -tocopherol (vitamin E) formulations often show poor intestinal absorption. Delivery of CoQ\n                    <jats:sub>10<\/jats:sub>\n                    and vitamin E was enhanced when used with a new formulation, NanoSolve (Lipoid GmbH, Ludwigshafen, Germany), as shown by an open, comparative monocenter, crossover study of 24 volunteers. Plasma CoQ\n                    <jats:sub>10<\/jats:sub>\n                    and vitamin E were determined from predose until +14 hours. To compare bioavailability, corrected maximum concentration, time to reach maximum concentration, and area under the curve from 0 to 14 hours were assessed. The NanoSolve test formulation contained 100 mg of CoQ\n                    <jats:sub>10<\/jats:sub>\n                    and 120 mg of vitamin E. The pure substances in hard gelatin capsules served as the reference. Although identical amounts of CoQ\n                    <jats:sub>10<\/jats:sub>\n                    and vitamin E were administered, absolutely higher serum concentrations of the active ingredients were achieved by the NanoSolve formulation than by the pure materials in gelatin capsules. The bioavailability of CoQ\n                    <jats:sub>10<\/jats:sub>\n                    increased fivefold after administration of the NanoSolve formulation, and the bioavailability of vitamin E was enhanced 10-fold both compared to the pure substances.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2006.254","type":"journal-article","created":{"date-parts":[[2007,12,25]],"date-time":"2007-12-25T09:01:14Z","timestamp":1198573274000},"page":"731-734","source":"Crossref","is-referenced-by-count":53,"title":["Increase of Bioavailability of Coenzyme Q\n                    <sub>10<\/sub>\n                    and Vitamin E"],"prefix":"10.1177","volume":"10","author":[{"given":"Rudi","family":"Wajda","sequence":"first","affiliation":[{"name":"Lipoid GmbH, Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Zirkel","sequence":"additional","affiliation":[{"name":"Lipoid GmbH, Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Schaffer","sequence":"additional","affiliation":[{"name":"Lipoid GmbH, Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,12,1]]},"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2006.254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2006.254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:13:13Z","timestamp":1777644793000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2006.254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1089\/jmf.2006.254"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2006.254","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}