{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:17:18Z","timestamp":1780528638772,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>\n                    This study aimed to evaluate the gastroprotective mechanism of action of the essential oil of\n                    <jats:italic toggle=\"yes\">Croton cajucara<\/jats:italic>\n                    Benth. (Euphorbiaceae) stem bark in ethanol-induced gastric ulcers and its\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    anti\u2013\n                    <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                    activity. The involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, nitric oxide, and nonprotein sulfhydryl compounds in the gastroprotective effect was determined in male Wistar rats. The minimum inhibitory concentration against\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    was determined\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . The results were analyzed by analysis of variance followed by the Dunnett test, and a\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    value less than 0.05 was considered to represent a statistically significant difference.\n                    <jats:italic toggle=\"yes\">C. cajucara<\/jats:italic>\n                    decreased ethanol-induced ulcer area in 100% of ulcers and decreased the histologic lesions. In the\n                    <jats:italic toggle=\"yes\">C. cajucara<\/jats:italic>\n                    group, the area marked by heat-shock protein-70 was significantly higher than the area in the control group; this finding was not seen for vasoactive intestinal peptide.\n                    <jats:italic toggle=\"yes\">C. cajucara<\/jats:italic>\n                    could not maintain glutathione levels close to those in the sham group. The gastric ulcer area of rats treated with the sulfhydryl compound blocker was decreased, but the ulcer area of rats treated with nitric oxide synthase inhibitor showed no alteration. The minimum inhibitory concentration obtained for\n                    <jats:italic toggle=\"yes\">C. cajucara<\/jats:italic>\n                    was 125\u2009\u03bcg\/mL. These findings suggest that sulfhydryl compounds and heat-shock protein-70, but not nitric oxide, glutathione, or vasoactive intestinal peptide, are involved in the\n                    <jats:italic toggle=\"yes\">C. cajucara<\/jats:italic>\n                    gastroprotective effect against ethanol-induced gastric ulcers.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2010.0173","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T16:21:59Z","timestamp":1302711719000},"page":"1011-1017","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Involvement of Glutathione, Sulfhydryl Compounds, Nitric Oxide, Vasoactive Intestinal Peptide, and Heat-Shock Protein-70 in the Gastroprotective Mechanism of\n                    <i>Croton cajucara<\/i>\n                    Benth. (Euphorbiaceae) Essential Oil"],"prefix":"10.1177","volume":"14","author":[{"given":"Ariane Leite","family":"Rozza","sequence":"first","affiliation":[{"name":"Universidade Estadual Paulista","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"de Mello Moraes","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio","family":"Kushima","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingos S\u00e1vio","family":"Nunes","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Ponta Grossa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9lia Akiko","family":"Hiruma-Lima","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Helena","family":"Pellizzon","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-009-0429-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.1217"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.03.030"},{"key":"e_1_3_3_5_2","first-page":"523","article-title":"Effect of essential oil obtained from Croton cajucara Benth","volume":"9","author":"Hiruma-Lima CA","year":"2002","unstructured":"Hiruma-Lima CA, , Gracioso JS, , Bighetti EJ et al. Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa. Phytomedicine, 2002; 9:523\u2013529.","journal-title":"on gastric ulcer healing and protective factors of the gastric mucosa. Phytomedicine"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nem186"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724080-00005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.030"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11030-0"},{"key":"e_1_3_3_10_2","first-page":"206","volume-title":"Plantas Medicinais no Brasil","author":"Lorenzi H","year":"2002","unstructured":"Lorenzi H, , Abreu Matos FJ. Plantas Medicinais no Brasil. Instituto Plantarum: Nova Odessa, 2002; 206."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957925"},{"key":"e_1_3_3_12_2","first-page":"529","article-title":"Medicinal plants popularly used in Brazilian Amazon","volume":"65","author":"Di Stasi LC","year":"1994","unstructured":"Di Stasi LC, , Hiruma CA, , Guimar\u00e3es EM, , Santos CM. Medicinal plants popularly used in Brazilian Amazon. Fitoterapia, 1994; 65:529\u2013540.","journal-title":"Fitoterapia"},{"key":"e_1_3_3_13_2","first-page":"402","article-title":"Ethnopharmacology and sustainable development of new plant-derived drugs","volume":"49","author":"Souza Brito ARM","year":"1997","unstructured":"Souza Brito ARM, , Nunes DS. Ethnopharmacology and sustainable development of new plant-derived drugs. Ci\u00ean Cult, 1997; 49:402\u2013408.","journal-title":"Ci\u00ean Cult"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422002000300016"},{"key":"e_1_3_3_15_2","first-page":"341","article-title":"Effects of an essential oil from the bark of Croton cajucara Benth","volume":"51","author":"Hiruma-Lima CA","year":"1999","unstructured":"Hiruma-Lima CA, , Gracioso JS, , Nunes DS, , Souza Brito ARM. Effects of an essential oil from the bark of Croton cajucara Benth. on experimental gastric ulcer models in rats and mice. J Pharm Pharmacol, 1999; 51:341\u2013346.","journal-title":"on experimental gastric ulcer models in rats and mice. J Pharm Pharmacol"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)97821-X"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2007.10.018"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.02.024"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5198(19)39795-1"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.11.036"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(85)13073-9"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00241-6"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.11.005"},{"key":"e_1_3_3_24_2","article-title":"Tentative standards M45-A and M02-A9","author":"Clinical and Laboratory Standards Institute: Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria","year":"2008","unstructured":"Clinical and Laboratory Standards Institute: Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria. Tentative standards M45-A and M02-A9. National Committee for Clinical Laboratory Standards, 2008.","journal-title":"National Committee for Clinical Laboratory Standards"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.09.036"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X03001405"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(01)00015-8"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6918(03)00033-7"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9571-9"},{"key":"e_1_3_3_31_2","first-page":"267","article-title":"Heat shock proteins: new keys to the development of cytoprotective therapies","volume":"5","author":"Tytell M","year":"2001","unstructured":"Tytell M, , Hooper PL. Heat shock proteins: new keys to the development of cytoprotective therapies. Expert Opin Ther Targets, 2001; 5:267\u2013287.","journal-title":"Expert Opin Ther Targets"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9946-6"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(03)00060-0"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2007.01.011"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0070122"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(21)00457-X"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-8-3"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1958"},{"key":"e_1_3_3_39_2","first-page":"103","article-title":"Nitric oxide (no)-releasing aspirin and (no) donors in protection of gastric mucosa against stress","volume":"59","author":"Kwiecie\u00f1 S","year":"2008","unstructured":"Kwiecie\u00f1 S, , Pawlik MW, , Brzozowski T et al. Nitric oxide (no)-releasing aspirin and (no) donors in protection of gastric mucosa against stress. J Physiol Pharmacol, 2008; 59:103\u2013115.","journal-title":"J Physiol Pharmacol"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03626.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1868"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.07.047"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.08.001"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2010.0173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2010.0173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2010.0173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:17:19Z","timestamp":1777645039000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2010.0173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1089\/jmf.2010.0173"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2010.0173","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}