{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:05:23Z","timestamp":1782363923655,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>\n                    Tea polyphenolics such as catechins are known to have the potential to inhibit many bacterial pathogens.\n                    <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                    has been identified as an etiologic agent in the development of gastric ulcer, peptic ulcer, gastritis, and many other stomach-related diseases. In this study, we investigated the effect of 9 tea extracts\u20143 different brands representing 4 different processed types (white, green, oolong, and black)\u2014on the inhibition of\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    . Extraction times of 2 and 5 minutes were compared. Most 5-minute extracts showed\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    inhibition, whereas 2-minute extracts only of Choice darjeeling black and Tazo white showed inhibition. No recovery was observed after the addition of 0.5 and 5\u2009mM proline, indicating that tea polyphenols do not inhibit\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    by inhibition of proline oxidation via proline dehydrogenase. Extracts that showed inhibition were further evaluated for their effect on beneficial lactic acid bacteria. None of the samples showed inhibition, suggesting that tea might be able to inhibit\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    without affecting the beneficial lactic acid bacteria. High-performance liquid chromatography indicated the presence of gallic acid, quercetin, caffeine, and tea catechins (including catechin, epicatechin, and epigallocatechin) in all the tea samples. Our study indicates that tea can be potentially used as a low-cost dietary support to combat\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    \u2013linked gastric diseases without affecting the beneficial intestinal bacteria.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2010.0237","type":"journal-article","created":{"date-parts":[[2011,6,11]],"date-time":"2011-06-11T15:12:06Z","timestamp":1307805126000},"page":"1321-1329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":69,"title":["Inhibitory Potential of Tea Polyphenolics and Influence of Extraction Time Against\n                    <i>Helicobacter pylori<\/i>\n                    and Lack of Inhibition of Beneficial Lactic Acid Bacteria"],"prefix":"10.1177","volume":"14","author":[{"given":"Chandrakant","family":"Ankolekar","sequence":"first","affiliation":[{"name":"University of Massachusetts","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia da Silva","family":"Pinto","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Labbe","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalidas","family":"Shetty","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"e_1_3_1_2_2","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"1","author":"Warren J","year":"1983","unstructured":"Warren J, , Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet, 1983; 1:1273\u20131275.","journal-title":"Lancet"},{"key":"e_1_3_1_3_2","first-page":"11","article-title":"The epidemiology of Helicobacter pylori","volume":"241","author":"Mitchell H","year":"1999","unstructured":"Mitchell H. The epidemiology of Helicobacter pylori. Curr Top Microbiol Immunol, 1999; 241:11\u201330.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35073084"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2004.06.024"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_3_1_7_2","first-page":"1607","article-title":"Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors","volume":"92","author":"You W","year":"2000","unstructured":"You W, , Zhang L, , Gail MH et al. Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors. JNCI Cancer Spec, 2000; 92:1607\u20131612.","journal-title":"JNCI Cancer Spec"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80005-4"},{"key":"e_1_3_1_9_2","first-page":"S6","article-title":"Helicobacter pylori: the size of the problem","volume":"43","author":"Parsonnet J","year":"1998","unstructured":"Parsonnet J. Helicobacter pylori: the size of the problem. Br Med J, 1998; 43:S6\u2013S9.","journal-title":"Br Med J"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529109098223"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5452.482"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01592.x"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.11.s1.11.x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2004.tb03521.x"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-002-3956-6"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837816"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i3.349"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00747.x"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.09.066"},{"key":"e_1_3_1_20_2","first-page":"73","article-title":"Lactic acid bacteria as probiotics","volume":"7","author":"Ljungh A","year":"2006","unstructured":"Ljungh A, , Wadstrom T. Lactic acid bacteria as probiotics. Curr Iss Intest Microbiol, 2006; 7:73\u201390.","journal-title":"Curr Iss Intest Microbiol"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1990.tb04887.x"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002633"},{"key":"e_1_3_1_23_2","first-page":"27","article-title":"Lactic acid bacteria and their effect on the immune system","volume":"2","author":"Perdig\u00f3n G","year":"2001","unstructured":"Perdig\u00f3n G, , Fuller R, , Raya R. Lactic acid bacteria and their effect on the immune system. Curr Iss Intest Microbiol, 2001; 2:27\u201342.","journal-title":"Curr Iss Intest Microbiol"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.1981.tb03024.x"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.1983.tb03515.x"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1998.00363.x"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(98)00086-6"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81743-7"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/08910609009140256"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/08910609009141546"},{"key":"e_1_3_1_31_2","first-page":"117","article-title":"Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas","volume":"56","author":"Friedman M","year":"2000","unstructured":"Friedman M. Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas. Mol Nutr Food Res, 2000; 56:117\u2013134.","journal-title":"Mol Nutr Food Res"},{"key":"e_1_3_1_32_2","first-page":"1","article-title":"A model for the role of proline-linked pentose-phosphate pathway in phenolic phytochemical biosynthesis and mechanism of action for human health and environmental applications","volume":"13","author":"Shetty K","year":"2004","unstructured":"Shetty K, , Wahlqvist M. A model for the role of proline-linked pentose-phosphate pathway in phenolic phytochemical biosynthesis and mechanism of action for human health and environmental applications. Asia Pac J Clin Nutr, 2004; 13:1\u201324.","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.12.8558-8564.2005"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/08905430701191205"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2008.09.012"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/08905430701534032"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.2.723-727.2000"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf9706080"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(93)90323-R"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2001.01271.x"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.65.126"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2010.0237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2010.0237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2010.0237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:17:29Z","timestamp":1777645049000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2010.0237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1089\/jmf.2010.0237"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2010.0237","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}