{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:35:13Z","timestamp":1777908913064,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Plinia cauliflora<\/jats:italic>\n                    (Mart.) Kausel, widespread in South America, has edible fruits, and its bark is commonly used against diarrhea and other disorders, on account of its astringency. Because diarrhea is still one of the most important causes of illness and death among children in developing countries, where the population turns to traditional medicine for its treatment, the present study determined the composition of fruit and leaf extracts of\n                    <jats:italic toggle=\"yes\">P. cauliflora<\/jats:italic>\n                    , analyzed the activity against diarrhea by antimicrobial and gastrointestinal motility, and evaluated the cytotoxicity of the extracts. Chemical composition was determined by high-performance liquid chromatograpy\u2013ultraviolet\/photodiode array detection. Antimicrobial activity was analyzed by agar diffusion and the microdilution method against etiological agents of diarrhea. The effect on gastrointestinal motility was analyzed using an experimental model in mice. Cytotoxicity was evaluated\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    with the fibroblast cell line SIRC CCL 60, and leaf extract showed a 50% inhibitory concentration of 0.48\u2009\u03bcg\/mL. Gallic acid, ellagic acid, and flavonoid derivatives were detected in the extracts. It was observed that fruit and leaf extracts showed some activity against\n                    <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    sp., and\n                    <jats:italic toggle=\"yes\">Shigella<\/jats:italic>\n                    sp. However, neither extract had any effect on gastrointestinal motility.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2010.0265","type":"journal-article","created":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T16:57:11Z","timestamp":1314118631000},"page":"1590-1596","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Chemical and Antidiarrheal Studies of\n                    <i>Plinia cauliflora<\/i>"],"prefix":"10.1177","volume":"14","author":[{"given":"Tatiana M.","family":"Souza-Moreira","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana A.","family":"Severi","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emerson","family":"Santos","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana Y.A.","family":"Silva","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner","family":"Vilegas","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9rida R.N.","family":"Salgado","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemeire C.L.R.","family":"Pietro","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-42302005000400022"},{"key":"e_1_3_3_3_2","first-page":"173","article-title":"Bacterial contamination of the lacteal contents of feeding bottles in metropolitan S\u00e3o Paulo, Brazil","volume":"76","author":"Morais TB","year":"1998","unstructured":"Morais TB, , Morais MB, , Sigulem DM. Bacterial contamination of the lacteal contents of feeding bottles in metropolitan S\u00e3o Paulo, Brazil. Bull World Health Organ, 1998; 76:173\u2013181.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/314593"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.662"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.265"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802000000100006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.444"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.03.017"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89101995000600002"},{"key":"e_1_3_3_11_2","volume-title":"\u00c1rvores Brasileiras: Manual de Identifica\u00e7\u00e3o e Cultivo de Plantas Arb\u00f3reas Nativas do Brasil","author":"Lorenzi H","year":"2000","unstructured":"Lorenzi H. \u00c1rvores Brasileiras: Manual de Identifica\u00e7\u00e3o e Cultivo de Plantas Arb\u00f3reas Nativas do Brasil, 3rd. Instituto Plantarum: Nova Odessa, Brazil, 2000.","edition":"3"},{"key":"e_1_3_3_12_2","first-page":"47","article-title":"Uso medicinal de esp\u00e9cies das fam\u00edlias Myrtaceae e Melastomataceae no Brasil","volume":"11","author":"Cruz AMV","year":"2004","unstructured":"Cruz AMV, , Kaplan MAC. Uso medicinal de esp\u00e9cies das fam\u00edlias Myrtaceae e Melastomataceae no Brasil. Floresta Ambiente, 2004; 11:47\u201352.","journal-title":"Floresta Ambiente"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4238(96)00910-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(03)00162-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-02398-3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)84277-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2006000300010"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00196-3"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.04.028"},{"key":"e_1_3_3_20_2","volume-title":"Approved Standard M2-A8","author":"Performance Standards for Antimicrobial Disk Susceptibility Tests","year":"2003","unstructured":"Performance Standards for Antimicrobial Disk Susceptibility Tests. Approved Standard M2-A8. National Committee for Clinical Laboratory Standards: Wayne, PA, 2003."},{"key":"e_1_3_3_21_2","volume-title":"Approved Standard M7-A6","author":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically","year":"2003","unstructured":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Approved Standard M7-A6. National Committee for Clinical Laboratory Standards: Wayne, PA, 2003."},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7012(02)00011-8"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1957.tb12290.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(81)90140-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2005000300007"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01606.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2007.11.018"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)01036-5"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-50532006000200010"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88458-0"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2007000400017"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)90500-4"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.01.021"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2005.05.015"},{"key":"e_1_3_3_35_2","first-page":"221","article-title":"Bioprospec\u00e7\u00e3o de atividade antioxidante e antimicrobiana da casca de Stryphnodendron adstringens (Mart.) Coville (Leguminosae-Mimosoidae)","volume":"28","author":"Souza TM","year":"2007","unstructured":"Souza TM, , Severi JA, , Silva VYA, , Santos E, , Pietro RCLR. Bioprospec\u00e7\u00e3o de atividade antioxidante e antimicrobiana da casca de Stryphnodendron adstringens (Mart.) Coville (Leguminosae-Mimosoidae) Rev Ciencias Farm B\u00e1sica Aplicada, 2007; 28:221\u2013226.","journal-title":"Rev Ciencias Farm B\u00e1sica Aplicada"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2007.557"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.11.008"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.07.025"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2007.04.008"},{"key":"e_1_3_3_40_2","first-page":"70","article-title":"Study of antidiarrhoeal activity of Calotropis gigantea r.b.r. in experimental animals","volume":"7","author":"Havagiray R","year":"2004","unstructured":"Havagiray R, , Ramesh C, , Sadhna K. Study of antidiarrhoeal activity of Calotropis gigantea r.b.r. in experimental animals. J Pharm Pharmaceut Sci, 2004; 7:70\u201375.","journal-title":"J Pharm Pharmaceut Sci"},{"key":"e_1_3_3_41_2","first-page":"39","article-title":"Anti-diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals","volume":"8","author":"Venkatesan N","year":"2005","unstructured":"Venkatesan N, , Vadivu T, , Sathiya N et al. Anti-diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals. J Pharm Sci, 2005; 8:39\u201345.","journal-title":"J Pharm Sci"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.07.014"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.08.036"},{"key":"e_1_3_3_44_2","volume-title":"Programme for Control of Diarrhoeal Diseases, Ninth Programme Report 1992\u20131993","author":"World Health Organization","year":"1994","unstructured":"World Health Organization. Programme for Control of Diarrhoeal Diseases, Ninth Programme Report 1992\u20131993. World Health Organization: Geneva, 1994."},{"key":"e_1_3_3_45_2","first-page":"120","volume-title":"World Health Report","author":"World Health Organization","year":"2004","unstructured":"World Health Organization. World Health Report. World Health Organization: Geneva, 2004; 120\u2013125."},{"key":"e_1_3_3_46_2","first-page":"2549","article-title":"Application of semiempirical method to estimate the cytotoxic activity of gallic acid and its related compounds","volume":"23","author":"Ishihara M","year":"2003","unstructured":"Ishihara M, , Sakagami H. Application of semiempirical method to estimate the cytotoxic activity of gallic acid and its related compounds. Anticancer Res, 2003; 23:2549\u20132552.","journal-title":"Anticancer Res"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00232-7"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.02.003"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2010.0265","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2010.0265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2010.0265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:17:37Z","timestamp":1777645057000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2010.0265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1089\/jmf.2010.0265"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2010.0265","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}