{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:35:33Z","timestamp":1777908933342,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>\n                    The methanolic extract of\n                    <jats:italic toggle=\"yes\">Grewia mollis<\/jats:italic>\n                    leaves was evaluated\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    for its antioxidant and hepatoprotective properties. Oxidative stress was induced in rats by administering carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) intraperitoneally at a dose of 0.6\u2009mL\/kg, whereas the crude plant extract and standard antioxidant (vitamin E) were administered at a dose of 5\u2009mg\/kg and 50\u2009mg\/kg, respectively. The effect of\n                    <jats:italic toggle=\"yes\">G. mollis<\/jats:italic>\n                    crude extracts and vitamin E on malondialdehyde (MDA) and liver function parameters such as protein, bilirubin, aspartate aminotransferase, and alanine aminotransferase were measured spectrophotometrically. The methanolic extract of\n                    <jats:italic toggle=\"yes\">G. mollis<\/jats:italic>\n                    leaves and vitamin E showed a significant (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;.05) hepatoprotective potential by lowering the serum levels of bilirubin, aspartate aminotransferase, and alanine aminotransferase and decreasing MDA levels in rats pretreated or post-treated with CCl\n                    <jats:sub>4<\/jats:sub>\n                    . Based on these results, it is concluded that\n                    <jats:italic toggle=\"yes\">G. mollis<\/jats:italic>\n                    leaves contain potent antioxidant compounds that could offer protection against hepatotoxicity as well as ameliorate preexisting liver damage and oxidative stress conditions.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2010.0285","type":"journal-article","created":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T14:31:34Z","timestamp":1314714694000},"page":"83-88","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Antioxidant, Hepatoprotective, and Ameliorative Effects of Methanolic Extract of Leaves of\n                    <i>Grewia mollis<\/i>\n                    Juss. on Carbon Tetrachloride\u2013Treated Albino Rats"],"prefix":"10.1177","volume":"15","author":[{"given":"Oiza","family":"Asuku","sequence":"first","affiliation":[{"name":"Ahmadu Bello University","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunday E.","family":"Atawodi","sequence":"additional","affiliation":[{"name":"Ahmadu Bello University","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elewechi","family":"Onyike","sequence":"additional","affiliation":[{"name":"Ahmadu Bello University","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"105","article-title":"Catalytic oxidation and antioxidant properties of thyme essential oils (Thymus vulgarae L)","volume":"78","author":"Juki\u0107 M","year":"2005","unstructured":"Juki\u0107 M, , Milo\u0161 M. 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Protective effect of Ziziphus mauritiana leaf extract on carbon tetrachloride-induced liver. Afr J Biotechnol, 2005; 4:1177\u20131179.","journal-title":"Afr J Biotechnol"},{"key":"e_1_3_2_14_2","first-page":"312","article-title":"Prevention of carbon tetrachloride-induced hepatotoxicity in rats by Adhatoda vasica leaves","volume":"36","author":"Paudit S","year":"2004","unstructured":"Paudit S, , Surh TK, , Jana U, , Debnata PK, , Sen S, , Bhattacharyga D. Prevention of carbon tetrachloride-induced hepatotoxicity in rats by Adhatoda vasica leaves. Indian J Pharmacol, 2004; 36:312\u2013313.","journal-title":"Indian J Pharmacol"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(98)00238-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.50.42"},{"key":"e_1_3_2_17_2","first-page":"128","article-title":"Antioxidant potential of African medicinal plants","volume":"4","author":"Atawodi SE","year":"2005","unstructured":"Atawodi SE. 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