{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:35:26Z","timestamp":1777908926186,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    Soybeans have been of interest of researchers because of the presence of isoflavones, a subclass of flavonoids, which have demonstrated anti-inflammatory activity. The aim of this study was investigate the anti-inflammatory activity of the methanol fraction from soybean, which contains mainly isoflavone glucosides and malonylglucosides. The anti-inflammatory activity of the methanol fraction from soybean was studied using croton oil\u2013induced mouse ear edema and carrageenan-induced pleurisy models. The methanol fraction inhibited the ear edema in a dose-dependent manner: 0.625\u2009mg\/kg by 44.23% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;.05), 1.25\u2009mg\/kg by 60.68% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;.01), and 2.5\u2009mg\/kg by 65.68% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;.01). Myeloperoxidase enzyme activity was reduced at the dose of 2.5\u2009mg\/kg (64.79%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;.05). No effects were seen on carrageenan-induced pleurisy at different doses of the methanol fraction (100 or 400\u2009mg\/kg). These results demonstrated that the methanol fraction containing conjugated isoflavones showed topical anti-inflammatory activity. There was no acute toxicity in Swiss mice after oral administration of the fraction, at doses of 1,000, 2,000, 3,000, and 4,000\u2009mg\/kg.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2010.0320","type":"journal-article","created":{"date-parts":[[2011,6,11]],"date-time":"2011-06-11T16:40:10Z","timestamp":1307810410000},"page":"1570-1575","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Soybean Methanol Fraction on Acute Inflammation"],"prefix":"10.1177","volume":"14","author":[{"given":"Vanessa da Silva","family":"Carrara","sequence":"first","affiliation":[{"name":"State University of Maring\u00e1","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciomar Bersani","family":"Amado","sequence":"additional","affiliation":[{"name":"State University of Maring\u00e1","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Oliveira","family":"de Melo","sequence":"additional","affiliation":[{"name":"State University of Maring\u00e1","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Marcos Gontijo","family":"Mandarino","sequence":"additional","affiliation":[{"name":"Brazilian Enterprise for Agricultural Research","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di\u00f3genes Apar\u00edcio Garcia","family":"Cortez","sequence":"additional","affiliation":[{"name":"State University of Maring\u00e1","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00107"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.3.593S"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.06.030"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00712-7"},{"key":"e_1_3_3_6_2","first-page":"1171","article-title":"Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. 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