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However, estrogen-induced cell proliferation in the uterus and mammary gland increases the risk for cancer in these organs. The lower incidence of mammary cancer in Asian women than in western women has been attributed to high intake of soy isoflavones, including genistein. Our previous work in the prepubertal rat uterus model showed that genistein (0.5\u2009mg\/kg body weight subcutaneously) caused an estradiol-like hypertrophy in myometrial and uterine luminal epithelial cells and an increase in RNA content in luminal epithelium; however, it did not induce cell proliferation, uterine eosinophilia, or endometrial edema. The present study investigated, in the same animal model, the effect of genistein administration (0.5\u2009mg\/kg body weight subcutaneously) before treatment with estradiol-17\u03b2 (0.33\u2009mg\/kg body weight subcutaneously) on uterine responses that were not induced by genistein. Pretreatment with this phytoestrogen completely inhibited estradiol-induced mitoses in uterine luminal epithelium, endometrial stroma, and myometrium and partially inhibited estradiol-induced uterine eosinophilia and endometrial edema. These findings indicate that genistein protects against estrogen-induced cell proliferation in the uterus and suggest that future studies should investigate the possibility of using this agent to decrease the risk for uterine cancer after hormone replacement therapy in climacteric women.<\/jats:p>","DOI":"10.1089\/jmf.2010.0349","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T16:45:36Z","timestamp":1306341936000},"page":"1597-1603","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Genistein Selectively Inhibits Estrogen-Induced Cell Proliferation and Other Responses to Hormone Stimulation in the Prepubertal Rat Uterus"],"prefix":"10.1177","volume":"14","author":[{"given":"Leonardo","family":"Gaete","sequence":"first","affiliation":[{"name":"University of Chile Medical School","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei N.","family":"Tchernitchin","sequence":"additional","affiliation":[{"name":"University of Chile Medical School","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Bustamante","sequence":"additional","affiliation":[{"name":"University of Chile Medical School","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Villena","sequence":"additional","affiliation":[{"name":"University of Valpara\u00edso School of Medicine","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Lemus","sequence":"additional","affiliation":[{"name":"University of Chile School of Chemical and Pharmaceutical Sciences","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Gidekel","sequence":"additional","affiliation":[{"name":"Adolfo Ib\u00e1\u00f1ez University","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Adolfo Ib\u00e1\u00f1ez University","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Carrillo","sequence":"additional","affiliation":[{"name":"University of Chile Medical School","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000241091.86268.6e"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.41.070172.001223"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5925"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod61.4.955"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0198"},{"key":"e_1_3_3_7_2","first-page":"1477","article-title":"Liaison de l'oestradiol dans les leucocytes polynucl\u00e9aires \u00e9osinophiles humains","volume":"280","author":"Tchernitchin A","year":"1974","unstructured":"Tchernitchin A, , Tchernitchin X, , Robel P, , Baulieu EE. 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