{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:35:48Z","timestamp":1777908948079,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>\n                    Previous studies showed that feeding diets containing the mature fruits of\n                    <jats:italic toggle=\"yes\">Sophora japonica<\/jats:italic>\n                    L. prevented body weight gain and reduced fat mass in high-fat diet-induced obese mice. This observation has led to the hypothesis that extracts from\n                    <jats:italic toggle=\"yes\">S. japonica<\/jats:italic>\n                    L. may inhibit adipocyte differentiation of preadipocytes. To elucidate the possible mechanisms for the anti-obesity action of\n                    <jats:italic toggle=\"yes\">S. japonica<\/jats:italic>\n                    L., its effects on adipocyte differentiation were investigated in C3H10T1\/2 mesenchymal stem cells and 3T3-L1 preadipocyte cells. The mature fruit of\n                    <jats:italic toggle=\"yes\">S. japonica L<\/jats:italic>\n                    . was partitioned with ethanol, hexane, dichloromethane, ethyl acetate (EtOAc), and butanol to identify the active fractions. The EtOAc fraction extracts inhibited morphological differentiation and lipid accumulation in the C3H10T1\/2 and 3T3-L1 preadipocytes. Molecular studies indicated that the EtOAc fraction extracts also reduced the expression of peroxisome proliferator-activated receptor \u03b3 and other adipocyte markers. Furthermore, among the fractions, the EtOAc fraction extracts had the highest total phenolic contents, suggesting that the polyphenols in the EtOAc fractions mediated the anti-adipogenic effects. Finally, high-performance liquid chromatography identified genistein, a known anti-adipogenic compound, as the probable mediator of the anti-adipogenic effects of the EtOAc fractions. This work validates the beneficial roles of\n                    <jats:italic toggle=\"yes\">S. japonica<\/jats:italic>\n                    L. in controlling body weight and obesity-related metabolic diseases.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2010.1324","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T16:51:27Z","timestamp":1297183887000},"page":"360-368","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Genistein Mediates the Anti-Adipogenic Actions of\n                    <i>Sophora japonica<\/i>\n                    L. Extracts"],"prefix":"10.1177","volume":"14","author":[{"given":"So-Ra","family":"Jung","sequence":"first","affiliation":[{"name":"Sungkyunkwan University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-Ryeong","family":"Gwon","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jina","family":"Lee","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Gyu","family":"Jo","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Joon","family":"Jeon","sequence":"additional","affiliation":[{"name":"Inha University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joung-Woo","family":"Hong","sequence":"additional","affiliation":[{"name":"Kyung Hee University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Moon","family":"Park","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye Won","family":"Park","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2010.42.1.007"},{"key":"e_1_3_3_3_2","first-page":"566","article-title":"Drug strategies for the treatment of obesity","volume":"6","author":"Alemany M","year":"2003","unstructured":"Alemany M, , Remesar X, , Fern\u00e1ndez-L\u00f3pez JA. 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