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EGCG prolonged sleeping time induced by pentobarbital (42\u2009mg\/kg, i.p.) and reduced sleeping latency induced by pentobarbital similarly to muscimol (0.2\u2009mg\/kg, i.p.), a GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor agonist in mice. EGCG also increased sleeping rate and sleeping time when co-administered with pentobarbital (28\u2009mg\/kg, i.p.) at a subhypnotic dosage. In addition, EGCG and pentobarbital increased chloride (Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) influx in primary cultured cerebellar cells. EGCG and pentobarbital decreased GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors \u03b1-subunit expression and had no effect on the expression of \u03b2- and \u03b3-subunits and of glutamic acid decarboxylase in the hippocampus of rats. In conclusion, the EGCG enhancement of Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    influx may play an important role in pentobarbital-induced sleeping behaviors.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2010.1529","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T17:31:41Z","timestamp":1314898301000},"page":"1456-1462","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["(\u2013)-Epigallocatechin-3-\n                    <i>O<\/i>\n                    -Gallate Augments Pentobarbital-Induced Sleeping Behaviors Through Cl\n                    <sup>\u2212<\/sup>\n                    Channel Activation"],"prefix":"10.1177","volume":"14","author":[{"given":"Kwang-Soon","family":"Park","sequence":"first","affiliation":[{"name":"Chungbuk National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Yi","family":"Han","sequence":"additional","affiliation":[{"name":"Chungbuk National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Cheul","family":"Moon","sequence":"additional","affiliation":[{"name":"Chungbuk National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Tae","family":"Hong","sequence":"additional","affiliation":[{"name":"Chungbuk National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Wan","family":"Oh","sequence":"additional","affiliation":[{"name":"Chungbuk National University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(92)90041-F"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.12.006"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02291.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.18.190"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.52.3.465"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.43.679"},{"key":"e_1_3_3_8_2","first-page":"217","article-title":"[Methodology of a study on insomnia in the general population]","volume":"28","author":"Ohayon MM","year":"2002","unstructured":"Ohayon MM. 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