{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:36:26Z","timestamp":1777908986068,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Arctium lappa<\/jats:italic>\n                    L. has been used in folk medicine as a diuretic, depurative, and digestive stimulant and in dermatological conditions. The mechanisms involved in the anti-ulcerogenic activity of the sesquiterpene onopordopicrin (ONP)-enriched fraction (termed the ONP fraction), obtained from\n                    <jats:italic toggle=\"yes\">A. lappa<\/jats:italic>\n                    leaves, were studied. The gastroprotective mechanism of the ONP fraction was evaluated in experimental\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    models in rodents, mimicking this disease in humans. ONP fraction (50\u2009mg\/kg, p.o.) significantly inhibited the mucosal injury induced by ethanol\/HCl solution (75%), indomethacin\/bethanecol (68.9%), and stress (58.3%). When the ONP fraction was investigated in pylorus ligature, it did not induce alteration in the gastric volume but did modify the pH and total acid concentration of gastric juice. ONP fraction significantly increased serum somatostatin levels (82.1\u00b14.1 vs. control group 12.7\u00b14\u2009pmol\/L) and decreased serum gastrin levels (62.6\u00b16.04 vs. control group 361.5\u00b18.2\u2009\u03bcU\/mL). Mucus production was not significantly altered by the ONP fraction. Gastroprotection by the ONP fraction was completely inhibited by\n                    <jats:italic toggle=\"yes\">N-<\/jats:italic>\n                    ethylmaleimide treatment and did not modify the effect in the animals pretreated with\n                    <jats:sc>l<\/jats:sc>\n                    -\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    <jats:sup>G<\/jats:sup>\n                    -nitroarginine methyl ester. These results suggest an antisecretory mechanism involved with the antiulcerogenic effect of the ONP fraction. However, only endogenous sulfhydryls play an important role in gastroprotection of the ONP fraction.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2011.0025","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T15:27:36Z","timestamp":1324567656000},"page":"378-383","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Anti-Ulcerogenic Mechanisms of the Sesquiterpene Lactone Onopordopicrin-Enriched Fraction from\n                    <i>Arctium lappa<\/i>\n                    L. (Asteraceae): Role of Somatostatin, Gastrin, and Endogenous Sulfhydryls and Nitric Oxide"],"prefix":"10.1177","volume":"15","author":[{"given":"Ana Beatriz Albino","family":"de Almeida","sequence":"first","affiliation":[{"name":"State University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson","family":"Luiz-Ferreira","sequence":"additional","affiliation":[{"name":"State University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00edra","family":"Cola","sequence":"additional","affiliation":[{"name":"State University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Di Pietro Magri","sequence":"additional","affiliation":[{"name":"State University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonia Maria","family":"Batista","sequence":"additional","affiliation":[{"name":"Federal University of Para\u00edba","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseilson Alves","family":"de Paiva","sequence":"additional","affiliation":[{"name":"State University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Roberto","family":"Trigo","sequence":"additional","affiliation":[{"name":"State University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba R.M.","family":"Souza-Brito","sequence":"additional","affiliation":[{"name":"State University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13123198"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0393"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.021"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1573(200012)14:8<581::AID-PTR776>3.0.CO;2-S"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.06.002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2007.07.003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15107153"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.6.0016"},{"key":"e_1_3_3_10_2","first-page":"721","article-title":"Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression","volume":"19","author":"Matsuzaki Y","year":"2008","unstructured":"Matsuzaki Y, , Koyama M, , Hitomi T et al. 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