{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:36:20Z","timestamp":1777908980816,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    The liver is a vital organ, and its function is generally impaired by chemicals. Some natural compounds have a protective role against liver diseases such as royal jelly (RJ). To our knowledge, there are no data available on the effect of RJ therapy on the levels of bio-element metabolisms and antioxidant enzyme activities in the carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    )-induced liver damage. Therefore, in the present study, we have investigated the role of RJ therapy in the trace and major elements and antioxidant enzymes in CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced hepatotoxicity in rats. Antioxidant enzyme activities decreased in the CCl\n                    <jats:sub>4<\/jats:sub>\n                    -treated group more than they did in the sham and RJ-administered groups. Many bio-element levels were also reduced in only the CCl\n                    <jats:sub>4<\/jats:sub>\n                    -treated group. This showed that the depletion of trace elements was related to erythrocyte antioxidant enzyme activities. RJ administration clearly increased the trace and major element levels and antioxidant enzyme activities in RJ groups. RJ may be used as functional foods because of their naturally high antioxidant potential and rich element content.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2012.0010","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T13:02:10Z","timestamp":1334667730000},"page":"747-752","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum and Liver Tissue Bio-Element Levels, and Antioxidant Enzyme Activities in Carbon Tetrachloride-Induced Hepatotoxicity: Protective Effects of Royal Jelly"],"prefix":"10.1177","volume":"15","author":[{"given":"Mustafa","family":"Cemek","sequence":"first","affiliation":[{"name":"Y\u0131ldiz Technical University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Afyon Kocatepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Emin","family":"B\u00fcy\u00fckokuro\u011flu","sequence":"additional","affiliation":[{"name":"Afyon Kocatepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"B\u00fcy\u00fckben","sequence":"additional","affiliation":[{"name":"Afyon Kocatepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Aymelek","sequence":"additional","affiliation":[{"name":"Ad\u0131yaman University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Ayaz","sequence":"additional","affiliation":[{"name":"Y\u0131ldiz Technical University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052270"},{"key":"e_1_3_2_3_2","first-page":"122","article-title":"Effect of aqueous extract of bitter leaf (Vernonia amygdalina Del) on carbon tetrachloride (CCl4) induced liver damage in albino Wistar rats","volume":"26","author":"Arhoghro EM","year":"2009","unstructured":"Arhoghro EM, , Ekpo KE, , Anosike EO, , Ibeh GO. Effect of aqueous extract of bitter leaf (Vernonia amygdalina Del) on carbon tetrachloride (CCl4) induced liver damage in albino Wistar rats. 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