{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:57:36Z","timestamp":1784609856665,"version":"3.55.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    Polycalcium is a mixture of Polycan and calcium lactate\u2013gluconate 1:9 (w\/w) with demonstrated antiosteoporosis activity\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    studies. These studies were a 4-week open-label, single-center trial to evaluate the efficacy of oral Polycalcium on bone metabolism and safety. In total, 30 healthy women (range 40\u201360 years) were administered 400\u2009mg of Polycalcium for 4 weeks. The primary efficacy parameter was urinary deoxypyridinoline (DPYR) levels, and serum osteocalcin (OSC), bone-specific alkaline phosphatase (BALP), urinary cross-linked C-telopeptide of type-1 collagen (CTx), urinary cross-linked N-telopeptide of type-1 collagen (NTx), calcium (Ca), and phosphorus (P) levels, which were evaluated for comparison before and after administration of Polycalcium. After 4 weeks of Polycalcium administration, 27 subjects completed the test plan. Three subjects withdrew their consent to participate. The values of blood OSC, BALP, serum Ca, and serum P from baseline to 4 weeks of treatment were changed by \u221228.44%, 14.37%, 6.11%, and 1.42%, respectively. Biomarkers of bone resorption: urinary DPYR, serum CTx, serum NTx, urinary Ca, and urinary P, at baseline after 4 weeks of treatment were changed by \u221213.40%, 6.67%, \u22125.13%, \u221222.43%, and \u22123.04%, respectively. Additionally, when considering the subjects' adverse effects and the results of the blood and urine tests over the 4-week trial period, the dose of 400\u2009mg Polycalcium showed efficacy for improving bone metabolism and was well tolerated and safe. Polycalcium was apparently safe and efficacious.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2012.2537","type":"journal-article","created":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T09:29:48Z","timestamp":1362994188000},"page":"263-267","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Safety and Efficacy of Polycalcium for Improving Biomarkers of Bone Metabolism: A 4-Week Open-Label Clinical Study"],"prefix":"10.1177","volume":"16","author":[{"given":"Jae-Suk","family":"Choi","sequence":"first","affiliation":[{"name":"Silla University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"Daegu Haany University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Daegu Haany University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Rae","family":"Cho","sequence":"additional","affiliation":[{"name":"Marine Bio-Industry Development Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Soon","family":"Choi","sequence":"additional","affiliation":[{"name":"Silla University"},{"name":"Silla University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Marine Bio-Industry Development Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00121-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1508"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.5.1.1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.785"},{"key":"e_1_3_3_6_2","first-page":"221","article-title":"Efficacy of glucosamine alendronate alone and in combination with dihydroquercetin for treatment of osteoporosis in animal model","volume":"135","author":"Muraleva NA","year":"2012","unstructured":"Muraleva NA, , Ofitserov EN, , Tikhonov VP, , Kolosova NG. Efficacy of glucosamine alendronate alone and in combination with dihydroquercetin for treatment of osteoporosis in animal model. Indian J Med Res, 2012; 135:221\u2013227.","journal-title":"Indian J Med Res"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20466"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.29085"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-2-199401150-00001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.08.019"},{"key":"e_1_3_3_11_2","first-page":"376","article-title":"Production of \u03b2-1,3\/1,6-glucan by Aureobasidium pullulans SM-2001","volume":"17","author":"Seo HP","year":"2002","unstructured":"Seo HP, , Kim JM, , Shin HD, , Kim TK, , Chang HJ, , Park BR, , Lee JW. Production of \u03b2-1,3\/1,6-glucan by Aureobasidium pullulans SM-2001. Kor J Biotechnol Bioeng, 2002; 17:376\u2013380.","journal-title":"Kor J Biotechnol Bioeng"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2007.08.011"},{"key":"e_1_3_3_13_2","first-page":"39","article-title":"Effect of \u03b2-glucan from Aureobasidium pullulans on rat rib fracture healing","volume":"24","author":"Lee HS","year":"2008","unstructured":"Lee HS, , Cho HR, , Moon SB, , Shin HD, , Yang KJ, , Park BR, , Jang HJ, , Kim LS, , Ku SK. Effect of \u03b2-glucan from Aureobasidium pullulans on rat rib fracture healing. Lab Anim Res, 2008; 24:39\u201344.","journal-title":"Lab Anim Res"},{"key":"e_1_3_3_14_2","first-page":"297","article-title":"Effects of polycan on bone metabolism in healthy perimenopausal women: a 12-week randomized, double-blind, placebo-controlled study","volume":"21","author":"Kim MG","year":"2006","unstructured":"Kim MG, , Ha KC, , Back HI, , Kim SY, , Kim JW, , Kim KY, , Cho HR, , Chae HJ, , Chae SW, , Kim DS. Effects of polycan on bone metabolism in healthy perimenopausal women: a 12-week randomized, double-blind, placebo-controlled study. Kor J Clin Pharm, 2006; 21:297\u2013304.","journal-title":"Kor J Clin Pharm"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040117"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1992.10718261"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.5352\/JLS.2011.21.8.1199"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0057"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/S002966510800699X"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256280"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110307"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-009-0141-z"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.2551"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23954"},{"key":"e_1_3_3_25_2","first-page":"297","article-title":"Evaluation of clinical efficacy of polycan for bone metabolism in Korean women: a randomized, double-blind, placebo-controlled clinical study","volume":"21","author":"Park SH","year":"2011","unstructured":"Park SH, , Kim SY, , Back HI, , Jeon JY, , Kim MG, , Chae SW, , Kim DS. 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