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The assessment was done by the investigation of serum-enzymatic and liver antioxidant activity, histopathological and ultrastructural changes in male Swiss mice, which were subjected to acute experimental intoxication with CCl\n                    <jats:sub>4<\/jats:sub>\n                    . Formulated and free flavonoid were orally given to mice for 7 days and then were intraperitoneally injected with 1.0\u2009mL\/kg CCl\n                    <jats:sub>4<\/jats:sub>\n                    on the 8th day. After 24\u2009h of CCl\n                    <jats:sub>4<\/jats:sub>\n                    administration, an increase in the levels of transaminases aspartate aminotransferase and alanine aminotransferase activities and malondialdehyde concentration occurred and a significant decrease in superoxide dismutase, catalase glutathione-peroxidase activities, and glutathione levels was detected as well. These were accompanied by extended centrilobular necrosis, steatosis, fibrosis, and an altered ultrastructure of hepatocytes. Pretreatment with formulated or free flavonoid retained the biochemical markers to control values. Histopathological and electron-microscopic examination confirmed the biochemical results. In conclusion, both NGN and NGN\/\u03b2-cyclodextrin complex showed antioxidant and hepatoprotective effects against injuries induced by CCl\n                    <jats:sub>4<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/jmf.2013.0007","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T15:36:14Z","timestamp":1394465774000},"page":"670-677","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["Antioxidant and Hepatoprotective Effects of Naringenin and Its \u03b2-Cyclodextrin Formulation in Mice Intoxicated with Carbon Tetrachloride: A Comparative Study"],"prefix":"10.1177","volume":"17","author":[{"given":"Anca","family":"Hermenean","sequence":"first","affiliation":[{"name":"Vasile Goldis Western University of Arad","place":["Romania"]},{"name":"Vasile Goldis Western University of 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