{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:37:11Z","timestamp":1777909031881,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>\n                    The extracts of\n                    <jats:italic toggle=\"yes\">Scutellaria baicalensis<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Acacia catechu<\/jats:italic>\n                    have been shown in previous studies to alleviate joint discomfort, reduce stiffness, and improve mobility by reducing the production of proinflammatory molecules over long periods of supplementation. The acute effects of intake of these extracts have not yet been investigated. Thus, we carried out a 1 week clinical trial to examine the extent to which UP446\u2014a natural proprietary blend of\n                    <jats:italic toggle=\"yes\">S. baicalensis<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">A. catechu<\/jats:italic>\n                    (UP446)\u2014decreases knee joint pain, mobility, and biomarkers of inflammation in comparison to naproxen. Seventy-nine men and women (40\u201390 years old) diagnosed as having mild to moderate osteoarthritis (OA) consumed either 500\u2009mg\/day of the UP446 supplement or 440\u2009mg\/day of naproxen for 1 week in a double-blind randomized control trial. Pain, knee range of motion (ROM), and overall physical activity were evaluated at the start and at the end of treatment. Fasting blood was collected to determine serum interleukins 1\u03b2 and 6, tumor necrosis factor-\u03b1, C-reactive protein, and hyaluronic acid. The UP446 group experienced a significant decrease in perceived pain (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =.009) time dependently. Stiffness was significantly reduced by both treatments (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =.002 UP446,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =.008 naproxen). Significant increases in mean ROM over time (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =.04) were found in the UP446 group. These findings suggest that UP446 is effective in reducing the physical symptoms associated with knee OA.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2013.0010","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T15:44:38Z","timestamp":1394466278000},"page":"707-713","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["A Combination of\n                    <i>Scutellaria Baicalensis<\/i>\n                    and\n                    <i>Acacia Catechu<\/i>\n                    Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee"],"prefix":"10.1177","volume":"17","author":[{"given":"Bahram H.","family":"Arjmandi","sequence":"first","affiliation":[{"name":"the Florida State University","place":["USA"]},{"name":"the Florida State University","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren T.","family":"Ormsbee","sequence":"additional","affiliation":[{"name":"the Florida State University","place":["USA"]},{"name":"the Florida State University","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus L.","family":"Elam","sequence":"additional","affiliation":[{"name":"the Florida State University","place":["USA"]},{"name":"the Florida State University","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara C.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Rutgers University","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Rahnama","sequence":"additional","affiliation":[{"name":"the Florida State University","place":["USA"]},{"name":"the Florida State University","place":["USA"]},{"name":"Faculty of Sports Sciences, University of Isfahan, Isfahan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Payton","sequence":"additional","affiliation":[{"name":"Oklahoma State University","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Brummel-Smith","sequence":"additional","affiliation":[{"name":"the Florida State University","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce P.","family":"Daggy","sequence":"additional","affiliation":[{"name":"the Florida State University","place":["USA"]},{"name":"the Florida State University","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24606"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.010637"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724070-00005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(96)80002-1"},{"key":"e_1_3_3_6_2","first-page":"825","article-title":"Efficacy and safety of avocado\/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. 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