{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:28:59Z","timestamp":1788830939085,"version":"build-2803163510"},"reference-count":47,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    Colorectal cancer (CRC) remains one of the most common malignancies and a leading cause of cancer-related deaths. Its prognosis remains poor for patients with several grades of this disease. This underscores the need for alternative modalities, such as herbal medicines, to treat this disease. A commonly used plant that appears to be of high medicinal value is\n                    <jats:italic toggle=\"yes\">Thymus vulgaris<\/jats:italic>\n                    L. However, the effects of this plant on the malignant behavior of human CRC cells remains poorly investigated. This study was undertaken to determine the anticancer efficacy of\n                    <jats:italic toggle=\"yes\">T. vulgaris<\/jats:italic>\n                    extract (TVE) in CRC cells. Our results show that TVE inhibits proliferation in a concentration- and time-dependent fashion. This decreased proliferation was concomitant with increased apoptotic cell death as evidenced by increased caspase3\/7 activity. Moreover, TVE also decreased adhesion to fibronectin in a concentration-dependent manner. The migratory and invasive capacities of HCT116 cells were significantly inhibited by TVE. Taken together, these data suggest that the TVE inhibits malignant phenotype of colon cancer cells. Therefore,\n                    <jats:italic toggle=\"yes\">T. vulgaris<\/jats:italic>\n                    could have an anticancer effect and that some of its bioactive compounds may prove to be effective treatment modalities for human CRC.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2013.3121","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T16:31:23Z","timestamp":1415377883000},"page":"54-59","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["<i>Thymus vulgaris<\/i>\n                    (Thyme) Inhibits Proliferation, Adhesion, Migration, and Invasion of Human Colorectal Cancer Cells"],"prefix":"10.1177","volume":"18","author":[{"given":"Afnan","family":"Al-Menhali","sequence":"first","affiliation":[{"name":"Qatar University","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Al-Rumaihi","sequence":"additional","affiliation":[{"name":"Qatar University","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Al-Mohammed","sequence":"additional","affiliation":[{"name":"Qatar University","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Al-Mazrooey","sequence":"additional","affiliation":[{"name":"Qatar University","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Al-Shamlan","sequence":"additional","affiliation":[{"name":"Qatar University","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaad","family":"AlJassim","sequence":"additional","affiliation":[{"name":"Qatar University","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noof","family":"Al-Korbi","sequence":"additional","affiliation":[{"name":"Qatar University","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Hussein","family":"Eid","sequence":"additional","affiliation":[{"name":"Qatar University","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Society AC: Estimated 2013 Cancer Deaths by Site Sex & Age Group. www.cancer.org\/research\/cancerfactsstatistics\/cancerfactsfigures2013\/ (accessed October3 2013)."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.839"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.12.014"},{"key":"e_1_3_3_5_2","unstructured":"Network NCI: Data Briefing: Colorectal Cancer Survival by Stage. 2009. www.ncin.org.uk\/publications\/data_briefings\/colorectal_cancer_survival_by_stage (accessed October3 2013)."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.206250"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7800-4-10"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02854894"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2004562"},{"key":"e_1_3_3_11_2","first-page":"83","article-title":"Essential oil composition of Thymus vulgaris L. and their uses","volume":"11","author":"Shabnum S","year":"2011","unstructured":"Shabnum S, , Wagay MG: Essential oil composition of Thymus vulgaris L. and their uses. 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