{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:38:19Z","timestamp":1777909099395,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>\n                    Humic acids (HAs) have a rather pleiotropic presence, however, their biological effects are still unclear. In this study, we focused on possible hepatoprotective effects of either HA alone or in combination with\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -glucan. Using a model of experimental hepatotoxicity caused by carbon tetrachloride (CCL\n                    <jats:sub>4<\/jats:sub>\n                    ), we showed that both HA and the glucan-HA combination offered significant protection against hepatotoxicity, with the combination offering superior effects. Our biochemical observations were confirmed by histological evaluation. Based on the experimental data, we conclude that whereas HA has significant effects, the synergy with glucan offers superior effects.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2014.0091","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T12:25:32Z","timestamp":1421324732000},"page":"572-577","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Humic Acid and Glucan: Protection Against Liver Injury Induced by Carbon Tetrachloride"],"prefix":"10.1177","volume":"18","author":[{"given":"Vaclav","family":"Vetvicka","sequence":"first","affiliation":[{"name":"University of Louisville","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Garcia-Mina","sequence":"additional","affiliation":[{"name":"Timac Agro International-Roullier Group","place":["Spain"]},{"name":"University of Navarra","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Proctor","sequence":"additional","affiliation":[{"name":"University of Louisville","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Yvin","sequence":"additional","affiliation":[{"name":"Timac Agro International","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1079\/JOH2002161"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins4111301"},{"key":"e_1_3_3_4_2","first-page":"81","article-title":"Combination of glucan, resveratrol and vitamin C demonstrates strong anti-tumor potential","volume":"32","author":"Vetvicka V","year":"2012","unstructured":"Vetvicka V, , Vetvickova J: Combination of glucan, resveratrol and vitamin C demonstrates strong anti-tumor potential. Anticancer Res, 2012; 32:81\u201388.","journal-title":"Anticancer Res"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4297\/najms.2011.3320"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300338"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1081\/PFC-100103738"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.1166"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00384-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2003-3-421"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2000.8954"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.0212"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.0178"},{"key":"e_1_3_3_14_2","first-page":"1267","article-title":"Tissue remodeling in liver diseases","volume":"18","author":"Giannelli G","year":"2003","unstructured":"Giannelli G, , Quaranta V, , Antonaci S: Tissue remodeling in liver diseases. Histol Histopathol, 2003; 18:1267\u20131274.","journal-title":"Histol Histopathol"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4639-00175"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563659309000384"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327110368420"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf903070a"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.08.011"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.01.007"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.2849"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-011-0580-4"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2011.06.007"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gexplo.2012.12.015"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3402\/ljm.v510.4891"},{"key":"e_1_3_3_26_2","first-page":"106","article-title":"Protective effect of leaf extract of Trichilla connaroides on hypercholesterolemia induced oxidative stress","volume":"6","author":"Prasanna GS","year":"2011","unstructured":"Prasanna GS, , Purnima A: Protective effect of leaf extract of Trichilla connaroides on hypercholesterolemia induced oxidative stress. Int J Pharmacol, 2011; 6:106\u2013112.","journal-title":"Int J Pharmacol"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06041.x"},{"key":"e_1_3_3_28_2","first-page":"4","article-title":"Veterinary pharmaceuticals containing humic acid for therapy and prophylaxis for gastrointestinal diseases of dog and cat","volume":"46","author":"Kuhnert M","year":"1991","unstructured":"Kuhnert M, , Bartels KP, , Kroll S, , Lange N: Veterinary pharmaceuticals containing humic acid for therapy and prophylaxis for gastrointestinal diseases of dog and cat. Monatshefte Veterinarmed, 1991; 46:4\u20138.","journal-title":"Monatshefte Veterinarmed"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3923\/pjn.2005.126.134"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3923\/ajava.2008.344.350"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408449509089886"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03714-6"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00126"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26783"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00037-9"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2014.0091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2014.0091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2014.0091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:22:35Z","timestamp":1777645355000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2014.0091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1089\/jmf.2014.0091"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2014.0091","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}