{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:38:28Z","timestamp":1777909108496,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Worldwide, the most highly consumed meat is of porcine origin. The production and distribution of swine meat are affected by diverse health matters, such as influenza and diarrhea, which cause head losses and require the use of antibiotics and other drugs in hog farms. To stimulate newborn piglet immune responses and increase resistance to infections, we developed a spray-drying technique to produce dried swine dialyzable spleen extract (sDSE), an immunomodulator. Based on the size-exclusion ultra performance liquid chromatography quantitative analysis, it was possible to recover up to 58% of the product after the drying process. The biological activity of orally administered dried sDSE increased mouse survival and induced cytokine production in a herpes infection model.<\/jats:p>","DOI":"10.1089\/jmf.2014.0176","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T17:06:23Z","timestamp":1428944783000},"page":"1239-1246","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Swine Dialyzable Spleen Extract as Antiviral Prophylaxis"],"prefix":"10.1177","volume":"18","author":[{"given":"Giovanna","family":"Merchand-Reyes","sequence":"first","affiliation":[{"name":"National Polytechnic Institute","place":["Mexico"]},{"name":"National Institute of Psychiatry","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenin","family":"Pav\u00f3n","sequence":"additional","affiliation":[{"name":"National Institute of Psychiatry","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"National Polytechnic Institute","place":["Mexico"]},{"name":"National Institute of Psychiatry","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"V\u00e1zquez-Leyva","sequence":"additional","affiliation":[{"name":"National Polytechnic Institute","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nohem\u00ed","family":"Salinas-Jazm\u00edn","sequence":"additional","affiliation":[{"name":"National Polytechnic Institute","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Velasco-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"National Autonomous University of Mexico","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Medina-Rivero","sequence":"additional","affiliation":[{"name":"National Polytechnic Institute","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia Mayra","family":"P\u00e9rez-Tapia","sequence":"additional","affiliation":[{"name":"National Polytechnic Institute","place":["Mexico"]},{"name":"National Polytechnic Institute","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"251","article-title":"Din\u00e1mica de la producci\u00f3n porcina en M\u00e9xico de 1980 a 2008","volume":"1","author":"Bobadilla Soto E","year":"2010","unstructured":"Bobadilla Soto E, , Espinoza Ortega A, , Mart\u00ednez Casta\u00f1eda FE: Din\u00e1mica de la producci\u00f3n porcina en M\u00e9xico de 1980 a 2008. Rev Mex Cienc Pecu, 2010; 1:251\u2013268.","journal-title":"Rev Mex Cienc Pecu"},{"key":"e_1_3_3_3_2","first-page":"3","article-title":"World pig production, opportunity or threat?","volume":"2006","author":"Orr DEJ","year":"2006","unstructured":"Orr DEJ, , Shen YR: World pig production, opportunity or threat?. Swine Nutrition Conference Proceedings, 2006; 2006:3\u20138.","journal-title":"Swine Nutrition Conference Proceedings"},{"key":"e_1_3_3_4_2","first-page":"8","author":"Meyer S","year":"2010","unstructured":"Meyer S, , Steiner L: Daily Livestock Report. 2010; 8.","journal-title":"Daily Livestock Report"},{"key":"e_1_3_3_5_2","unstructured":"Garc\u00eda Arias KI: Panorama del porcino. Mexico: Financiera Nacional de Desarrollo Agropecuario Rural Forestal y Pesquera 2014."},{"key":"e_1_3_3_6_2","article-title":"Animal health, animal welfare, pre-harvest food safety and protecting the environment as key elements of animal production","author":"Blaha T","year":"2005","unstructured":"Blaha T: Animal health, animal welfare, pre-harvest food safety and protecting the environment as key elements of animal production. Proceedings of The International Society for Animal Hygiene (ISAH), 2005.","journal-title":"Proceedings of The International Society for Animal Hygiene (ISAH)"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1865-1682.2011.01291.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2013_308"},{"key":"e_1_3_3_9_2","first-page":"215","article-title":"Presencia de animales seropositivos al s\u00edndrome reproductivo y respiratorio porcino en Nuevo Le\u00f3n","volume":"39","author":"Salinas Mel\u00e9ndez JA","year":"2008","unstructured":"Salinas Mel\u00e9ndez JA, , Lara Arias J, , Flores Andrade H, , \u00c1valos Ram\u00edrez R, , Z\u00e1rate Ramos JJ, , Riojas Vald\u00e9s V, et al: Presencia de animales seropositivos al s\u00edndrome reproductivo y respiratorio porcino en Nuevo Le\u00f3n. Vet M\u00e9x, 2008; 39:215\u2013221.","journal-title":"Vet M\u00e9x"},{"key":"e_1_3_3_10_2","author":"M\u00e9xico reporta mortal virus porcino en 17 estados","year":"2014","unstructured":"M\u00e9xico reporta mortal virus porcino en 17 estados. El Universal, 2014 May 22.","journal-title":"El Universal"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114970"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2008.04.016"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.09.004"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.06.003"},{"key":"e_1_3_3_15_2","first-page":"134","article-title":"Indications, usage, and dosage of the transfer factor","volume":"54","author":"Berron-Perez R","year":"2007","unstructured":"Berron-Perez R, , Chavez-Sanchez R, , Estrada-Garcia I, , Espinosa-Padilla S, , Cortez-Gomez R, , Serrano-Miranda E, et al: Indications, usage, and dosage of the transfer factor. Rev Alerg Mex, 2007; 54:134\u2013139.","journal-title":"Rev Alerg Mex"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dit.2013.04.002"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02628665"},{"key":"e_1_3_3_18_2","first-page":"116","article-title":"Transference factor in moderate and severe atopic dermatitis","volume":"43","author":"Navarro Cruz D","year":"1996","unstructured":"Navarro Cruz D, , Serrano Miranda E, , Orea M, , Estrada Parra S, , Teran Ortiz L, , Gomez Vera J, et al.: Transference factor in moderate and severe atopic dermatitis. Rev Alerg Mex, 1996; 43:116\u2013123.","journal-title":"Rev Alerg Mex"},{"key":"e_1_3_3_19_2","first-page":"273","article-title":"Transfer factors in medical therapy","volume":"137","author":"Sanchez-Gonzalez DJ","year":"2011","unstructured":"Sanchez-Gonzalez DJ, , Sosa-Luna CA, , Vasquez-Moctezuma I: Transfer factors in medical therapy. Med Clin (Barc), 2011; 137:273\u2013277.","journal-title":"Med Clin (Barc)"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.077"},{"key":"e_1_3_3_21_2","unstructured":"Biotechnology P Pierce\u2122 BCA Protein Assay Kit. Rockford IL."},{"key":"e_1_3_3_22_2","article-title":"Herpes murine model as a biological assay to test dialyzable leukocyte extracts activity","author":"Salinas-Jazm\u00edn N","unstructured":"Salinas-Jazm\u00edn N, , Estrada-Parra S, , Becerril-Garc\u00eda MA, , Lim\u00f3n-Flores Y, , V\u00e1zquez-Leyva S, , Medina-Rivero E, et al.: Herpes murine model as a biological assay to test dialyzable leukocyte extracts activity. J Immunol Res Article ID 146305, in press.","journal-title":"J Immunol Res"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-6-22"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.01.011"},{"key":"e_1_3_3_25_2","first-page":"S87","article-title":"Immunotherapy with transfer factor of recurrent herpes simplex type I","volume":"26","author":"Estrada-Parra S","year":"1995","unstructured":"Estrada-Parra S, , Chavez-Sanchez R, , Ondarza-Aguilera R, , Correa-Meza B, , Serrano-Miranda E, , Monges-Nicolau A, et al.: Immunotherapy with transfer factor of recurrent herpes simplex type I. Arch Med Res, 1995; 26:S87\u2013S92.","journal-title":"Arch Med Res"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/267871"},{"key":"e_1_3_3_27_2","first-page":"46","article-title":"El extracto leucocitario dializable aumenta la concentracion de interfer\u00f3n gamma serico en cerdos destetados","author":"Hernandez-Peralta P","year":"2014","unstructured":"Hernandez-Peralta P, , Perez-Tapia SM, , Limon-Flores AY, , Vazquez-Leyva S, , Estrada Parra S, , Sanchez-Betancourt I, et al.: El extracto leucocitario dializable aumenta la concentracion de interfer\u00f3n gamma serico en cerdos destetados. Arch Med Vet, 2014; 46.","journal-title":"Arch Med Vet"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/194064"},{"key":"e_1_3_3_29_2","first-page":"853","article-title":"Dialyzable leukocyte extracts activate TLR-2 on monocytes","volume":"9","author":"Garcia-Hernandez U","year":"2014","unstructured":"Garcia-Hernandez U, , Robledo-Avlia FH, , Alvarez-Jimenez V, , Rodriguez-Cortes O, , Wong-Baeza I, , Serafin-Lopez J, et al.: Dialyzable leukocyte extracts activate TLR-2 on monocytes. Nat Prod Commun, 2014; 9:853\u2013856.","journal-title":"Nat Prod Commun"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2014.0176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2014.0176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2014.0176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:22:46Z","timestamp":1777645366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2014.0176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1089\/jmf.2014.0176"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2014.0176","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}