{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:09:58Z","timestamp":1787008198897,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>\n                    The potential antioxidant and anti-inflammatory activities of\n                    <jats:italic toggle=\"yes\">Acanthopanax senticosus<\/jats:italic>\n                    Harms were evaluated and its effect on the human Kv1.3 potassium channel was detected. The ethyl acetate fraction possessed the highest phenolic (289.19\u00b17.43\u2009mg tannic acid equivalents\/g) and flavonoid (10.80\u00b10.67\u2009mg quercetin equivalents\/g) contents and exhibited stronger antioxidant effects than other fractions in most of the antioxidant assays. On the other hand, the dichloromethane (CH\n                    <jats:sub>2<\/jats:sub>\n                    Cl\n                    <jats:sub>2<\/jats:sub>\n                    ) fraction showed the strongest anti-inflammatory activity. The CH\n                    <jats:sub>2<\/jats:sub>\n                    Cl\n                    <jats:sub>2<\/jats:sub>\n                    fraction inhibited the expression of inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    and interleukin 1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    mRNAs, and the generation of reactive oxygen species in lipopolysaccharide-induced RAW 264.7 cells. Also, the peak current was inhibited 54.8%\u00b117% by the CH\n                    <jats:sub>2<\/jats:sub>\n                    Cl\n                    <jats:sub>2<\/jats:sub>\n                    fraction in voltage-clamp recording from\n                    <jats:italic toggle=\"yes\">Xenopus laevis<\/jats:italic>\n                    oocytes. Our research demonstrated that fractions of\n                    <jats:italic toggle=\"yes\">A. senticosus<\/jats:italic>\n                    have great potential to be a source of edible antioxidant and anti-inflammatory agents.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2014.3182","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T17:48:40Z","timestamp":1414086520000},"page":"468-475","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Different Solvent Fractions of\n                    <i>Acanthopanax senticosus<\/i>\n                    Harms Exert Antioxidant and Anti-Inflammatory Activities and Inhibit the Human Kv1.3 Channel"],"prefix":"10.1177","volume":"18","author":[{"given":"Yunyao","family":"Jiang","sequence":"first","affiliation":[{"name":"Kangwon National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong-Hyeon","family":"Wang","sequence":"additional","affiliation":[{"name":"Kangwon National University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,4,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5530\/ax.2012.3.4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(11)60204-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.04.074"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2013.09.026"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.04.002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2008.03.027"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.05.012"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.07.030"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.04.003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.11.031"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2004.02.018"},{"key":"e_1_3_3_13_2","first-page":"1299","article-title":"Antioxidant activity of fractions from 70% methanolic extract of Sonchus oleraceus L","volume":"17","author":"Yin J","year":"2008","unstructured":"Yin J, , Heo SI, , Jung MJ, , Wang MH: Antioxidant activity of fractions from 70% methanolic extract of Sonchus oleraceus L. 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