{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:06:47Z","timestamp":1785226007545,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Cordyceps militaris<\/jats:italic>\n                    is a medicinal mushroom and its bioactive compound, cordycepin, is reported to have many pharmacological activities. The goal of this study was to investigate the effects of\n                    <jats:italic toggle=\"yes\">C. militaris<\/jats:italic>\n                    extract (CME) and cordycepin on osteoclast differentiation\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and on an inflammatory bone loss\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . In RAW 264.7 cells, CME and cordycepin showed dose-dependent inhibition of receptor activator of the nuclear factor kappa B (NF-\n                    <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                    B) ligand (RANKL)-induced osteoclast differentiation by TRAP (tartrate-resistant acid phosphatase) staining. Moreover, the mRNA expression of osteoclastogenesis-related genes (TRAP, cathepsin K, MMP-9, and NFATc1) was also inhibited by CME and cordycepin. Also, cordycepin significantly inhibited RANKL-induced phosphorylation of p38 and NF-\n                    <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                    B, but not that of other members of mitogen-activated protein kinase families. To examine the effect of CME on bone loss\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    , we used a mouse model of lipopolysaccharide (LPS)-mediated bone loss. Micro-CT analysis of the femurs showed that LPS treatment caused bone loss. However, bone loss was significantly attenuated in mice treated with CME. These results suggest that cordycepin or\/and CME have inhibitory effects on osteoclast differentiation\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and that they suppress inflammatory bone loss\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/jmf.2014.3215","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T16:40:53Z","timestamp":1426783253000},"page":"446-452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["<i>Cordyceps militaris<\/i>\n                    Mushroom and Cordycepin Inhibit RANKL-Induced Osteoclast Differentiation"],"prefix":"10.1177","volume":"18","author":[{"given":"Jinhee","family":"Kim","sequence":"first","affiliation":[{"name":"Gachon University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyejin","family":"Lee","sequence":"additional","affiliation":[{"name":"Gachon University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Sung","family":"Kang","sequence":"additional","affiliation":[{"name":"Gachon University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Hoon","family":"Chun","sequence":"additional","affiliation":[{"name":"Gachon University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwi Seo","family":"Hwang","sequence":"additional","affiliation":[{"name":"Gachon University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,4,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0977"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(99)00061-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.3.377"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.10.042"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.03.023"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-008-9139-0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd916"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00105-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00369-6"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02444"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.11.077"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/07388551.2014.900604"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.07.010"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2008.01.027"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-11-r116"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-007-0467-y"},{"key":"e_1_3_3_19_2","first-page":"137","article-title":"Effect of cordycepin (3\u2032-deoxyadenosine) on hematogenic lung metastatic model mice","volume":"19","author":"Nakamura K","year":"2005","unstructured":"Nakamura K, , Konoha K, , Yoshikawa N, et al.: Effect of cordycepin (3\u2032-deoxyadenosine) on hematogenic lung metastatic model mice. In Vivo, 2005; 19:137\u2013141.","journal-title":"In Vivo"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.06.047"},{"key":"e_1_3_3_21_2","first-page":"1134","article-title":"Inhibitory effects of cordycepin (3\u2032-deoxyadenosine), a component of Cordyceps militaris, on human platelet aggregation induced by thapsigargin","volume":"17","author":"Cho HJ","year":"2007","unstructured":"Cho HJ, , Cho JY, , Rhee MH, , Kim HS, , Lee HS, , Park HJ: Inhibitory effects of cordycepin (3\u2032-deoxyadenosine), a component of Cordyceps militaris, on human platelet aggregation induced by thapsigargin. J Microbiol Biotechnol, 2007; 17:1134\u20131138.","journal-title":"J Microbiol Biotechnol"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/172460080401900108"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00222a004"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X08006387"},{"key":"e_1_3_3_25_2","first-page":"243","article-title":"The condition of production of artificial fruiting body of Cordyceps militaris","volume":"27","author":"Choi IY CJ","year":"1999","unstructured":"Choi IY CJ, , Lee WH, et al.: The condition of production of artificial fruiting body of Cordyceps militaris. Korean J Mycol, 1999; 27:243\u2013248.","journal-title":"Korean J Mycol"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.61.03.0002"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.3.0367"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.10.001"},{"key":"e_1_3_3_29_2","first-page":"311","article-title":"Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase\/type IV collagenase=gelatinase B) in osteoclasts: Implications for bone resorption","volume":"72","author":"Okada Y","year":"1995","unstructured":"Okada Y, , Naka K, , Kawamura K, et al.: Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase\/type IV collagenase=gelatinase B) in osteoclasts: Implications for bone resorption. Lab Invest, 1995; 72:311\u2013322.","journal-title":"Lab Invest"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00332.x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.011"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2010.03.003"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080211"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80232-4"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.11.007"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.7.1200"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030015"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.06.004"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-008-0153-8"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21951"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10041"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2014.3215","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2014.3215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2014.3215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:22:57Z","timestamp":1777645377000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2014.3215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1089\/jmf.2014.3215"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2014.3215","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}