{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:38:45Z","timestamp":1777909125459,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    In a previous study, we demonstrated that a\n                    <jats:italic toggle=\"yes\">Valeriana officinalis<\/jats:italic>\n                    extract could attenuate increases in serum corticosterone levels in a mouse model of physical and psychological stress. In addition, our results showed that the extract could modulate serotonin (5-HT) and norepinephrine (NE) turnover in the hippocampus and amygdala region. In this study, we intended to investigate the effects of valerenic acid (VA), the main component of\n                    <jats:italic toggle=\"yes\">V. officinalis<\/jats:italic>\n                    extract, on corticosterone levels in serum in normal mice and monoamine turnover in hippocampus-amygdala homogenates in a mouse model of physical and psychological stress. To determine the minimum dose of VA for antianxiety effect, eight-week-old ICR mice were orally administered VA (0.2, 0.5, and 1.0\u2009mg\/kg\/0.3\u2009mL) once daily for 3 weeks to probe for immobility time and serum corticosterone levels. At a VA dose of 0.5 and 1.0\u2009mg\/kg, animals showed a decrease in the duration of immobility time and serum corticosterone levels. To confirm the antianxiety effect of VA, eight-week-old ICR mice received VA at a dose of 0.5\u2009mg\/kg, orally, once daily for 3 weeks, before being subjected to physical or psychological stress for 3 days, in a specially designed communication box, followed by estimation of levels of monoamines and their metabolites in the hippocampus-amygdala region. In conclusion, VA administration at 0.5\u2009mg\/kg can mitigate the physical and psychological stress response by decreasing the turnover of 5-HT to 5-hydroxyindoleacetic acid and NE to 3-methoxy-4-hydroxyphenylethyleneglycol sulfate in the hippocampus and amygdala.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2014.3412","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T12:05:51Z","timestamp":1436961951000},"page":"1333-1339","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Valerenic Acid Protects Against Physical and Psychological Stress by Reducing the Turnover of Serotonin and Norepinephrine in Mouse Hippocampus-Amygdala Region"],"prefix":"10.1177","volume":"18","author":[{"given":"Hyo Young","family":"Jung","sequence":"first","affiliation":[{"name":"Seoul National University","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Young","family":"Yoo","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Min","family":"Nam","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Whi","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Kangwon National University","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyoung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Korea Food Research Institute","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghee","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea Food Research Institute","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeo Sung","family":"Yoon","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Koo","family":"Hwang","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198505013.003.0006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00268-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(90)90044-Z"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00080-7"},{"issue":"1","key":"e_1_3_3_6_2","first-page":"4","article-title":"Relationship of neurotransmitters to the symptoms of major depressive disorder","volume":"69","author":"Nutt DJ","year":"2008","unstructured":"Nutt DJ: Relationship of neurotransmitters to the symptoms of major depressive disorder. 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