{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:41:29Z","timestamp":1792856489243,"version":"4.5.0"},"reference-count":160,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>The human gut microbiome impacts human brain health in numerous ways: (1) Structural bacterial components such as lipopolysaccharides provide low-grade tonic stimulation of the innate immune system. Excessive stimulation due to bacterial dysbiosis, small intestinal bacterial overgrowth, or increased intestinal permeability may produce systemic and\/or central nervous system inflammation. (2) Bacterial proteins may cross-react with human antigens to stimulate dysfunctional responses of the adaptive immune system. (3) Bacterial enzymes may produce neurotoxic metabolites such as D-lactic acid and ammonia. Even beneficial metabolites such as short-chain fatty acids may exert neurotoxicity. (4) Gut microbes can produce hormones and neurotransmitters that are identical to those produced by humans. Bacterial receptors for these hormones influence microbial growth and virulence. (5) Gut bacteria directly stimulate afferent neurons of the enteric nervous system to send signals to the brain via the vagus nerve. Through these varied mechanisms, gut microbes shape the architecture of sleep and stress reactivity of the hypothalamic-pituitary-adrenal axis. They influence memory, mood, and cognition and are clinically and therapeutically relevant to a range of disorders, including alcoholism, chronic fatigue syndrome, fibromyalgia, and restless legs syndrome. Their role in multiple sclerosis and the neurologic manifestations of celiac disease is being studied. Nutritional tools for altering the gut microbiome therapeutically include changes in diet, probiotics, and prebiotics.<\/jats:p>","DOI":"10.1089\/jmf.2014.7000","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T16:28:20Z","timestamp":1416241700000},"page":"1261-1272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":575,"title":["The Gut Microbiome and the Brain"],"prefix":"10.1177","volume":"17","author":[{"given":"Leo","family":"Galland","sequence":"first","affiliation":[{"name":"Foundation for Integrated Medicine","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,12,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058040"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/mp\/sst149"},{"key":"e_1_3_2_4_2","first-page":"153","article-title":"Alzheimer's disease and the microbiome","volume":"7","author":"Surjyadipta B","year":"2013","unstructured":"Surjyadipta B, , Lukiw WJ, Alzheimer's disease and the microbiome. Front Cell Neurosci, 2013; 7:153\u2013160.","journal-title":"Front Cell Neurosci"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.01.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712038105"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.141"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812874106"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01620.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201100042"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010529108"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01796.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063388"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.01.014"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-5-3"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90559-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3346"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.009"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.7.2715-2721.1994"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.002253"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03469.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-834561"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.3.R828"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2013.782315"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(02)52007-9"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm231"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028330"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.12.001"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508055591"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05791.x"},{"issue":"6","key":"e_1_3_2_32_2","first-page":"57","article-title":"[Microecological aspects of small intestinal bacterial overgrowth syndrome]","author":"Bondarenko VM","year":"2006","unstructured":"Bondarenko VM, , Lykova EA, , Matsulevich TV: [Microecological aspects of small intestinal bacterial overgrowth syndrome]. Zh Mikrobiol Epidemiol Immunobiol, 2006;(6):57\u201363.","journal-title":"Zh Mikrobiol Epidemiol Immunobiol"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.06.010"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00236.2013"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1530\/JME-13-0079"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.02.003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415174111"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.08.021"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken140"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.485325"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-996-0009-z"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0021-0"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.05.018"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0949-9"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32836208de"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10554"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/654143"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70290-X"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.775666"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00869-13"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-113"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00362-14"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.061366"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-8-232"},{"key":"e_1_3_2_55_2","article-title":"The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease","author":"Olivares M","year":"2014","unstructured":"Olivares M, , Neef A, , Castillejo G, et al.: The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease. Gut, 2014;pii: gutjnl-2014\u2013306931.","journal-title":"Gut"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22459"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0709471"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-109"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030744"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-5-19"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90522-4"},{"key":"e_1_3_2_62_2","first-page":"160","article-title":"Ammonia levels and the severity of hepatic encephalopathy","volume":"24","author":"Qureshi MO","year":"2014","unstructured":"Qureshi MO, , Khokhar N, , Shafqat F: Ammonia levels and the severity of hepatic encephalopathy. J Coll Physicians Surg Pak, 2014; 24:160\u2013163.","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-009-0419-3"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12128502"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-011-0145-5"},{"key":"e_1_3_2_66_2","first-page":"621","article-title":"Increased d-lactic acid intestinal bacteria in patients with chronic fatigue syndrome","volume":"23","author":"Sheedy JR","year":"2009","unstructured":"Sheedy JR, , Wettenhall RE, , Scanlon D, et al.: Increased d-lactic acid intestinal bacteria in patients with chronic fatigue syndrome. In Vivo, 2009; 23:621\u2013628.","journal-title":"In Vivo"},{"key":"e_1_3_2_67_2","first-page":"902","article-title":"Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria","volume":"29","author":"Maes M","year":"2008","unstructured":"Maes M, , Leunis JC: Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett, 2008; 29:902\u2013910.","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)83765-8"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2009.09.024"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/342583"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2011-4381"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.9738\/CC169"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-782"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-011-9269-4"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1177\/0884533613496432"},{"key":"e_1_3_2_76_2","first-page":"277","article-title":"Oral glutamine challenge improves the performance of psychometric tests for the diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis","volume":"22","author":"Irimia R","year":"2013","unstructured":"Irimia R, , Stanciu C, , Cojocariu C, et al.: Oral glutamine challenge improves the performance of psychometric tests for the diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis. J Gastrointestin Liver Dis, 2013; 22:277\u2013281.","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0150-z"},{"key":"e_1_3_2_78_2","first-page":"544","article-title":"Is it a medical error if we do not screen cirrhotic patients for minimal hepatic encephalopathy?","volume":"94","author":"Quero Guill\u00e9n JC","year":"2002","unstructured":"Quero Guill\u00e9n JC, , Groeneweg M, , Jim\u00e9nez S\u00e1enz M, et al.: Is it a medical error if we do not screen cirrhotic patients for minimal hepatic encephalopathy?. Rev Esp Enferm Dig, 2002; 94:544\u2013557.","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00190.2011"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00152.2012"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.221"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.219"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9687-y"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20194"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31822fecfe"},{"key":"e_1_3_2_86_2","first-page":"17","article-title":"Starch for health","volume":"9","author":"Subari\u0107 D","year":"2012","unstructured":"Subari\u0107 D, , A\u010dkar D, , Babi\u0107 J, , Mili\u010devi\u0107 B: Starch for health. Med Glas (Zenica), 2012; 9:17\u201322.","journal-title":"Med Glas (Zenica)"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04757.x"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.3.397"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.07.007"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800100-4.00003-9"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.05.010"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0213-6"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2485"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2012.08.001"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140216"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1100"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2013.08.017"},{"issue":"2","key":"e_1_3_2_98_2","first-page":"251","article-title":"Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions","volume":"59","author":"Tazoe H","year":"2008","unstructured":"Tazoe H, , Otomo Y, , Kaji I, et al.: Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J Physiol Pharmacol, 2008; 59 Suppl 2:251\u2013262.","journal-title":"J Physiol Pharmacol"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016088108"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000025"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2013.089"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2167-7"},{"issue":"3","key":"e_1_3_2_103_2","first-page":"A116","article-title":"Gut bacterial and fermentation profiles are altered in children with autism","volume":"25","author":"Wang L","year":"2010","unstructured":"Wang L, et al.: Gut bacterial and fermentation profiles are altered in children with autism. J Gastroenterol Hepatol, 2010; 25(Suppl. 3):A116\u2013A119.","journal-title":"J Gastroenterol Hepatol"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1253"},{"key":"e_1_3_2_105_2","article-title":"Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children","volume":"8","author":"Kang DW","year":"2013","unstructured":"Kang DW, , Park JG, , Ilhan ZE, et al.: Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS One, 2013; 8:e68322.","journal-title":"PLoS One"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46101-0"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.11.6459-6465.2004"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.05212-11"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02212940"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02829968"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024585"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00261-11"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.1.286-291.2000"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-42"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-012-0337-0"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076993"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1307491"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.024"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2007.11.005"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2003.11.004"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1537100100"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.10.023"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2007.09.010"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665110001710"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1159\/000322350"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2008.06.032"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510004319"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511005137"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509990766"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.043"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602546"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-1-6"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-8-4"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2007.10.001"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283572ffa"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102999108"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2478"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.04.052"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318227414a"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005963107"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110591"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002355107"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.174136"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2009.01900.x"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2006.06.013"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2010.02294.x"},{"key":"e_1_3_2_147_2","first-page":"62","article-title":"Patient-centered care: antecedents, triggers, and mediators","volume":"12","author":"Galland L","year":"2006","unstructured":"Galland L: Patient-centered care: antecedents, triggers, and mediators. Altern Ther Health Med, 2006; 12:62\u201370.","journal-title":"Altern Ther Health Med"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2009.01982.x"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1208344"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1159\/000354907"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.2.229"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.05.015"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(94)76965-4"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2005.04.013"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000039"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.058"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu5010234"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109400"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3145"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.11.001"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000589"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2014.7000","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2014.7000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2014.7000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:23:19Z","timestamp":1777645399000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2014.7000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":160,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1089\/jmf.2014.7000"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2014.7000","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}