{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:13:10Z","timestamp":1790057590849,"version":"4.0.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Capsicum baccatum<\/jats:italic>\n                    is the most consumed red pepper species in Brazil. Our previous studies demonstrated the anti-inflammatory properties of its crude extract, whose activity is yet to be fully characterized. Herein, we examined the anti-inflammatory\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    effects of enriched extracts obtained through bioguided fractionation as dichloromethane (DCM), butanol (BUT), and residual aqueous (RAq) extracts and its influence on inflammatory mediators produced by macrophages\n                    <jats:italic toggle=\"yes\">in vitro.<\/jats:italic>\n                    We demonstrated that all\n                    <jats:italic toggle=\"yes\">C. baccatum<\/jats:italic>\n                    extracts presented anti-inflammatory activity\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . In addition, we showed that BUT and RAq were more effective in inhibiting the neutrophil migration induced by carrageenan (Cg) to peritoneal cavity and both extracts inhibited paw edema induced by Cg, prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    , and histamine in mice. Furthermore, the pretreatment with\n                    <jats:italic toggle=\"yes\">C. baccatum<\/jats:italic>\n                    extracts significantly reduced the levels of myeloperoxidase (MPO) in the paw tissues of mice compared with the carrageenan group. Once again, RAq and BUT caused the greatest reduction in MPO levels. Moreover, it was demonstrated for the first time that\n                    <jats:italic toggle=\"yes\">C. baccatum<\/jats:italic>\n                    inhibited the nitric oxide and tumor necrosis factor-alpha production by lipopolysaccharide\/interferon gamma (IFN-\u03b3)-stimulated macrophages. These anti-inflammatory effects seem to be at least, in part, independent of capsaicin. Hence, red pepper has bioactive compounds and might be used to develop food-derived extracts to treat related inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2015.0101","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T16:40:59Z","timestamp":1471452059000},"page":"759-767","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Red Pepper (\n                    <i>Capsicum baccatum<\/i>\n                    ) Extracts Present Anti-Inflammatory Effects\n                    <i>In Vivo<\/i>\n                    and Inhibit the Production of TNF-\u03b1 and NO\n                    <i>In Vitro<\/i>"],"prefix":"10.1177","volume":"19","author":[{"given":"Alexandra","family":"Allemand","sequence":"first","affiliation":[{"name":"Laboratory of Phytochemistry and Organic Synthesis, Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."},{"name":"Laboratory of Cell and Molecular Immunology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Franco","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Laboratory of Phytochemistry and Organic Synthesis, Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Rigon","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Laboratory of Phytochemistry and Organic Synthesis, Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Moreno","sequence":"additional","affiliation":[{"name":"Graduate Program in Biotechnology, Catholic University Dom Bosco, Campo Grande, MS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Roosevelt Torres","family":"Rom\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Molecular Immunology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Gosmann","sequence":"additional","affiliation":[{"name":"Laboratory of Phytochemistry and Organic Synthesis, Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.02.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0907654"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.03.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.01.045"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2015.03.006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202872"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986712800672049"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.08.006"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/524019"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6685"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.1118"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.11.005"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)99017-1"},{"key":"e_1_3_3_16_2","first-page":"178","article-title":"Estimation of total flavonoid content in propolis by two complementary colorimetric methods","volume":"10","author":"Chang CC","year":"2002","unstructured":"Chang CC, , Yang MH, , Wen HM, , Chern JC: Estimation of total flavonoid content in propolis by two complementary colorimetric methods. 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