{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:41:43Z","timestamp":1789389703802,"version":"build-2803163510"},"reference-count":51,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Fructus mume<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">F. mume<\/jats:italic>\n                    ), the unripe fruit of\n                    <jats:italic toggle=\"yes\">Prunus mume<\/jats:italic>\n                    , has long been used in Asian countries to treat cough and chronic diarrhea. We previously reported that\n                    <jats:italic toggle=\"yes\">F. mume<\/jats:italic>\n                    exerts anti-inflammatory effects in a model of chronic cerebral hypoperfusion (CCH), a key etiological factor of vascular dementia (VaD). The present study was performed to investigate the protective effects of an ethanolic extract of\n                    <jats:italic toggle=\"yes\">F. mume<\/jats:italic>\n                    on the inflammatory response and cholinergic dysfunction in a model of CCH induced by bilateral common carotid artery occlusion (BCCAo) in Wistar rats. Rats were assigned to three treatment groups: sham plus vehicle, BCCAo plus vehicle, and BCCAo plus\n                    <jats:italic toggle=\"yes\">F. mume<\/jats:italic>\n                    extract (200\u2009mg\/kg).\n                    <jats:italic toggle=\"yes\">F. mume<\/jats:italic>\n                    was administered by oral gavage from days 21 to 42 following BCCAo. Glial cell numbers were measured in the white matter and hippocampus. The hippocampal expressions of proinflammatory cytokines, angiotensin-II (Ang-II), receptor for advanced glycation end products (RAGE), and mitogen-activated protein kinase (MAPKs) were also evaluated. Choline acetyltransferase (ChAT) levels in the hippocampus and basal forebrain were examined. Rats with BCCAo showed an increase in the number of glial cells and levels of proinflammatory cytokines, Ang-II, RAGE, and MAPKs, all of which were significantly attenuated by\n                    <jats:italic toggle=\"yes\">F. mume<\/jats:italic>\n                    treatment.\n                    <jats:italic toggle=\"yes\">F. mume<\/jats:italic>\n                    administration also restored ChAT expression in the basal forebrain and hippocampus following chronic BCCAo. These results suggest that\n                    <jats:italic toggle=\"yes\">F. mume<\/jats:italic>\n                    is a potentially valuable drug or nutraceutical for the treatment of VaD.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2015.3512","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T17:02:01Z","timestamp":1451408521000},"page":"196-204","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["<i>Fructus mume<\/i>\n                    Ethanol Extract Prevents Inflammation and Normalizes the Septohippocampal Cholinergic System in a Rat Model of Chronic Cerebral Hypoperfusion"],"prefix":"10.1177","volume":"19","author":[{"given":"Min-Soo","family":"Kim","sequence":"first","affiliation":[{"name":"Korea Institute of Oriental Medicine"},{"name":"Konkuk University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hye","family":"Bang","sequence":"additional","affiliation":[{"name":"Korea Institute of Oriental Medicine"},{"name":"Keimyung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Soo","family":"Han","sequence":"additional","affiliation":[{"name":"Konkuk University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Won","family":"Kang","sequence":"additional","affiliation":[{"name":"Wonkwang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Kyung","family":"Jeon","sequence":"additional","affiliation":[{"name":"Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2010.00527.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132639"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.008"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00010"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2003.03825.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070093"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-334"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2004.00143.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.02.008"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.08.036"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.11.058"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.03.029"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.5607\/en.2011.20.2.92"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.09.021"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf980960t"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.198"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.7783\/KJMCS.2011.19.1.016"},{"key":"e_1_3_3_19_2","article-title":"Ameliorating effects of ethanol extract of Fructus mume on scopolamine-induced memory impairment in mice","volume":"2015","author":"Kim MS","year":"2015","unstructured":"Kim MS, , Jeon WK, , Lee KW, , Park YH, , Han JS: Ameliorating effects of ethanol extract of Fructus mume on scopolamine-induced memory impairment in mice. 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