{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:08:10Z","timestamp":1779433690495,"version":"3.53.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>\n                    Many natural substances were screened to develop nutraceuticals that reduce menopausal symptoms. A complex of\n                    <jats:italic toggle=\"yes\">Cirsium japonicum<\/jats:italic>\n                    var.\n                    <jats:italic toggle=\"yes\">maackii<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Thymus vulgaris<\/jats:italic>\n                    extracts, named MS-10, had significant positive effects. Under a low concentration of estrogen, which represents postmenopausal physiological conditions, MS-10 had beneficial effects on estrogen receptor-expressing MCF-7 cells by reversibly enhancing estrogen activity. In addition, in the ovariectomized rat model, changes in bone-specific alkaline phosphatase activity and osteocalcin, as well as low-density lipoprotein cholesterol and triglyceride levels were significantly decreased by MS-10. These results show that MS-10 protected bone health and reduced metabolic disturbances. Furthermore, in a clinical study, all menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, palpitations, formication, and headache, as well as colpoxerosis, were significantly improved by taking MS-10 for 90 days. Therefore, the evidence supports that MS-10 is an effective natural substance that can safely improve menopausal symptoms, including colpoxerosis.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2015.3547","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T15:44:48Z","timestamp":1454687088000},"page":"228-237","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Natural Substance MS-10 Improves and Prevents Menopausal Symptoms, Including Colpoxerosis, in Clinical Research"],"prefix":"10.1177","volume":"19","author":[{"given":"Yoo-Hun","family":"Noh","sequence":"first","affiliation":[{"name":"Chung-Ang University"},{"name":"Famenity, Inc."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Naturesense, Inc."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ah","family":"Lee","sequence":"additional","affiliation":[{"name":"Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing Fu","family":"Yin","sequence":"additional","affiliation":[{"name":"Famenity, Inc."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiae","family":"Park","sequence":"additional","affiliation":[{"name":"Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo Yeol","family":"Lee","sequence":"additional","affiliation":[{"name":"Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Bok","family":"Lee","sequence":"additional","affiliation":[{"name":"Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kwang","family":"Kim","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Dankook University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonhwa","family":"Jeong","sequence":"additional","affiliation":[{"name":"Dankook University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon-Chul","family":"Myung","sequence":"additional","affiliation":[{"name":"Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Jun","family":"Kang","sequence":"additional","affiliation":[{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"105","article-title":"Mood, hormones and quality of life","volume":"159","author":"Mazza M","year":"2008","unstructured":"Mazza M, , Bria P, , Taranto C, , Janiri L, , Mazza S: Mood, hormones and quality of life. 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