{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:08:15Z","timestamp":1779433695189,"version":"3.53.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2016,7]]},"abstract":"\n Abnormal expression of pro-inflammatory mediators such as cell adhesion molecules and cytokines has been implicated in various inflammatory skin diseases, including atopic dermatitis. In this study, we investigated the anti-inflammatory activity of\n Aronia melanocarpa<\/jats:italic>\n concentrate (\n AC<\/jats:italic>\n ) and its action mechanisms using\n in vivo<\/jats:italic>\n and\n in vitro<\/jats:italic>\n skin inflammation models. Topical application of\n AC<\/jats:italic>\n on mouse ears significantly suppressed 12-\n O<\/jats:italic>\n -tetradecanoylphorbol-13-acetate (TPA)-induced ear edema formation, as judged by measuring ear thickness and weight, and histological analysis. Topical administration of\n AC<\/jats:italic>\n also reduced the expression of pro-inflammatory cytokines such as TNF-\n \u03b1<\/jats:italic>\n , IL-1\n \u03b2<\/jats:italic>\n , and IL-6 in TPA-stimulated mouse ears. Pretreatment with\n AC<\/jats:italic>\n suppressed TNF-\n \u03b1<\/jats:italic>\n -induced ICAM-I expression and subsequent monocyte adhesiveness in human keratinocyte cell line HaCaT. In addition,\n AC<\/jats:italic>\n significantly decreased intracellular reactive oxygen species (ROS) generation as well as mitogen-activated protein kinase (MAPK) activation in TNF-\n \u03b1<\/jats:italic>\n -stimulated HaCaT cells.\n AC<\/jats:italic>\n and its constituent cyanidin 3-glucoside also attenuated TNF-\n \u03b1<\/jats:italic>\n -induced IKK activation, I\n \u03ba<\/jats:italic>\n B degradation, p65 phosphorylation\/nuclear translocation, and p65 DNA binding activity in HaCaT cells. Overall, our results indicate that\n AC<\/jats:italic>\n exerts anti-inflammatory activities by inhibiting expression of pro-inflammatory mediators\n in vitro<\/jats:italic>\n and\n in vivo<\/jats:italic>\n possibly through suppression of ROS-MAPK-NF-\n \u03ba<\/jats:italic>\n B signaling pathways. Therefore,\n AC<\/jats:italic>\n may be developed as a therapeutic agent to treat various inflammatory skin diseases.\n <\/jats:p>","DOI":"10.1089\/jmf.2015.3624","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T19:07:07Z","timestamp":1466622427000},"page":"654-662","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Aronia melanocarpa<\/i>\n Concentrate Ameliorates Pro-Inflammatory Responses in HaCaT Keratinocytes and 12-\n O<\/i>\n -Tetradecanoylphorbol-13-Acetate-Induced Ear Edema in Mice"],"prefix":"10.1177","volume":"19","author":[{"given":"Ah Ra","family":"Goh","sequence":"first","affiliation":[{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Soo","family":"Youn","sequence":"additional","affiliation":[{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Yeon","family":"Yoo","sequence":"additional","affiliation":[{"name":"Gangneung-Wonju National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo Ho","family":"Won","sequence":"additional","affiliation":[{"name":"Kangwon National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Zin","family":"Han","sequence":"additional","affiliation":[{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Sung","family":"Lim","sequence":"additional","affiliation":[{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinseu","family":"Park","sequence":"additional","affiliation":[{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(02)00136-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.4.1323"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-001-0276-9"},{"key":"e_1_3_3_5_2","first-page":"469","article-title":"Curcumin attenuates the expression of IL-1\u03b2, IL-6, and TNF-\u03b1 as well as cyclin E in TNF-\u03b1-treated HaCaT cells; NF-\u03baB and MAPKs as potential upstream targets","volume":"19","author":"Cho JW","year":"2007","unstructured":"Cho JW, , Lee KS, , Kim CW: Curcumin attenuates the expression of IL-1\u03b2, IL-6, and TNF-\u03b1 as well as cyclin E in TNF-\u03b1-treated HaCaT cells; NF-\u03baB and MAPKs as potential upstream targets. 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