{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:08:12Z","timestamp":1779433692615,"version":"3.53.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>\n                    Lactoferrin (LF) has beneficial effects against various diseases. However, the effects of LF on liver fibrosis in systematic lupus erythematosus (SLE) are unknown. In this study, NZB\/W F1 mice were utilized to investigate the effects of LF on SLE. Experiments reveal that LF significantly increases glutathione and 1,1-diphenyl-2-picryl-hydrazyl levels and significantly decreased malondialdehyde levels in both serum and liver in NZB\/W F1 mice. LF also lowered matrix metalloproteinase-9 activity and liver inflammatory indices, such as aminotransferase and alanine aminotransferase. Notably, significantly decreased expression of fibrotic related molecules, including transforming growth factor (TGF)-\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    1, tumor necrosis factor-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    , interleukin-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    , and TGF-\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    1 receptor, were observed in the livers of NZB\/W F1 mice that had been treated with LF. Significantly, suppressed Smad2\/3 signaling,\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    -smooth muscle actin, and collagen deposition were also detected. These findings reveal that LF has beneficial effects on SLE by increasing antioxidant activities and ameliorating liver inflammation and fibrosis, suggesting the therapeutic effectiveness of LF against SLE.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2015.3634","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T19:10:40Z","timestamp":1466622640000},"page":"670-677","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Lactoferrin Increases Antioxidant Activities and Ameliorates Hepatic Fibrosis in Lupus-Prone Mice Fed with a High-Cholesterol Diet"],"prefix":"10.1177","volume":"19","author":[{"given":"Hung-An","family":"Chen","sequence":"first","affiliation":[{"name":"Chi-Mei Medical Center","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ching","family":"Chiu","sequence":"additional","affiliation":[{"name":"Chunghua Christian Hospital","place":["Taiwan"]},{"name":"Chunghua Christian Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"China Medical University","place":["Taiwan"]},{"name":"China Medical University","place":["Taiwan"]},{"name":"Asia University","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chou","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai-Ching","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan."},{"name":"Immunology Research Center, School of Medicine, Chung Shan Medical University, Taichung, Taiwan."},{"name":"Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor-Show","family":"Tzang","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan."},{"name":"Immunology Research Center, School of Medicine, Chung Shan Medical University, Taichung, Taiwan."},{"name":"Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan."},{"name":"Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"69","volume-title":"Dubois' Lupus Erythematosus","author":"Hahn BH","year":"1992","unstructured":"Hahn BH: An overview of the pathogenesis of systemic lupus erythematosus. 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