{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:31:13Z","timestamp":1791045073696,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    The antiobesity effect of 5,7-dimethoxyflavone (DMF) was evaluated in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese C57BL\/6J mice. The accumulation of lipid droplets and triglycerides in adipocytes was dose dependently suppressed by DMF through inhibition of adipogenesis. DMF downregulated the adipogenic transcription factors (peroxisome proliferator-activated receptor [PPAR]\n                    <jats:italic toggle=\"yes\">\u03b3<\/jats:italic>\n                    , CCAAT\/enhancer binding protein [C\/EBP]\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    , and sterol regulatory element-binding protein-1c [SREBP-1c]) and lipid synthesis enzymes (fatty acid synthase [FAS], acetyl-CoA carboxylase [ACC], lipoprotein lipase [LPL], and HMG-CoA reductase [HMGR]). AMP-activated protein kinase (AMPK) and AMPK related lipolytic proteins in differentiated adipocytes were activated by DMF. In the animal model, oral administration of DMF (50\u2009mg\/kg\/day for 6 weeks) significantly decreased body weight gain without affecting food intake. Elevated serum levels of total cholesterol and low-density lipoprotein cholesterol were suppressed by DMF. Fat pad masses were reduced in DMF-treated obese mice, as evidenced by reduced adipocyte size. DMF altered the expression of adipogenic transcription factors in epididymal fat tissue. In addition, DMF attenuated HFD-induced nonalcoholic fatty liver disease by decreasing hepatic triglyceride accumulation. Overall, these results suggest that DMF is a potential natural agent for attenuating obesity and other obesity-related metabolic syndromes.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2016.3800","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T16:38:21Z","timestamp":1478709501000},"page":"1111-1119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["5,7-Dimethoxyflavone Attenuates Obesity by Inhibiting Adipogenesis in 3T3-L1 Adipocytes and High-Fat Diet-Induced Obese C57BL\/6J Mice"],"prefix":"10.1177","volume":"19","author":[{"given":"Youngwoo","family":"Song","sequence":"first","affiliation":[{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Bo","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhee","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongwook","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Kwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300020"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2010.10719844"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phanu.2013.01.001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2391"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.09.016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2066"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.5.9.1538"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80306-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.12.001"},{"key":"e_1_3_3_11_2","article-title":"Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1\/AMPK pathway","volume":"8","author":"He Y","year":"2013","unstructured":"He Y, , Li Y, , Zhao T, et al.: Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1\/AMPK pathway. PLoS One, 2013; 8:e70135.","journal-title":"PLoS One"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.011"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.01.033"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2858"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-009-1900-z"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01236.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.35.686"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.01.014"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.06.153"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5042"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80211-7"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003593200"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400373-JLR200"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.6.1412"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-015-0948-y"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-010-0461-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/205915"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2016.3800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2016.3800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2016.3800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T12:32:32Z","timestamp":1779712352000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2016.3800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1089\/jmf.2016.3800"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2016.3800","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}