{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:06:36Z","timestamp":1790258796753,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n                    Chronic liver diseases with portal hypertension are characterized by a progressive vasodilatation, endothelial dysfunction, and NADPH oxidase-derived vascular oxidative stress, which have been suggested to involve the angiotensin system. This study evaluated the possibility that oral intake of polyphenol-rich blackcurrant juice (PRBJ), a rich natural source of antioxidants, prevents endothelial dysfunction in a rat model of cirrhosis induced by chronic bile duct ligation (CBDL), and, if so, determined the underlying mechanism. Male Wistar rats received either control drinking water or water containing 60\u2009mg\/kg gallic acid equivalents of PRBJ for 3 weeks before undergoing surgery with CBDL or sham surgery. After 4 weeks, vascular reactivity was assessed in mesenteric artery rings using organ chambers. Both the acetylcholine-induced nitric oxide (NO)- and endothelium-dependent hyperpolarization (EDH)-mediated relaxations in mesenteric artery rings were significantly reduced in CBDL rats compared to sham rats. An increased level of oxidative stress and expression of NADPH oxidase subunits, COX-2, NOS, and of the vascular angiotensin system are observed in arterial sections in the CBDL group. Chronic intake of PRBJ prevented the CBDL-induced impaired EDH-mediated relaxation, oxidative stress, and expression of the different target proteins in the arterial wall. In addition, PRBJ prevented the CBDL-induced increase in the plasma level of proinflammatory cytokines (interleukin [IL]-1\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    , monocyte chemotactic protein 1, and tumor necrosis factor\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    ) and the decrease of the anti-inflammatory cytokine, IL-4. Altogether, these observations indicate that regular ingestion of PRBJ prevents the CBDL-induced endothelial dysfunction in the mesenteric artery most likely by normalizing the level of vascular oxidative stress and the angiotensin system.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2017.0078","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T11:45:08Z","timestamp":1521805508000},"page":"390-399","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Polyphenol-Rich Blackcurrant Juice Prevents Endothelial Dysfunction in the Mesenteric Artery of Cirrhotic Rats with Portal Hypertension: Role of Oxidative Stress and the Angiotensin System"],"prefix":"10.1177","volume":"21","author":[{"given":"Sherzad","family":"Rashid","sequence":"first","affiliation":[{"name":"University of Strasbourg","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noureddine","family":"Idris-Khodja","sequence":"additional","affiliation":[{"name":"University of Strasbourg","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Auger","sequence":"additional","affiliation":[{"name":"University of Strasbourg","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Kevers","sequence":"additional","affiliation":[{"name":"University of Li\u00e8ge","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Pincemail","sequence":"additional","affiliation":[{"name":"University of Li\u00e8ge","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Alhosin","sequence":"additional","affiliation":[{"name":"University of Strasbourg","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Boehm","sequence":"additional","affiliation":[{"name":"University of Strasbourg","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Oswald-Mammosser","sequence":"additional","affiliation":[{"name":"University of Strasbourg","place":["France"]},{"name":"University Hospitals of Strasbourg","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie B.","family":"Schini-Kerth","sequence":"additional","affiliation":[{"name":"University of Strasbourg","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,4,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00336.2005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.10.040"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00057-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00037-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.alc.0000189280.19073.28"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00319-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.05.022"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328337da1d"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i47.6385"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9574LSF"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-9140(01)00550-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.08.013"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280314"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf049696w"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf902263n"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032039"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.01.036"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.145326"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7458"},{"key":"e_1_3_3_21_2","first-page":"1719","article-title":"Effect of selective bowel decontamination with norfloxacin on spontaneous bacterial peritonitis, translocation, and survival in an animal model of cirrhosis","volume":"21","author":"Runyon BA","year":"1995","unstructured":"Runyon BA, , Borzio M, , Young S, et al.: Effect of selective bowel decontamination with norfloxacin on spontaneous bacterial peritonitis, translocation, and survival in an animal model of cirrhosis. 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