{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:40:35Z","timestamp":1777909235795,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n                    This study investigated whether\n                    <jats:italic toggle=\"yes\">Nardostachys jatamansi DC<\/jats:italic>\n                    extract (NJE) improved insulin sensitivity and suppressed hepatic glucose production in an animal model of type 2 diabetes. C57BL\/KsJ-\n                    <jats:italic toggle=\"yes\">db\/db<\/jats:italic>\n                    mice were divided into three dietary groups: regular diet (control), NJE, and rosiglitazone. After 6 weeks of feeding, blood glucose, glycosylated hemoglobin, and plasma insulin levels were significantly lower in NJE than in diabetic control group mice. The oral glucose tolerance test also revealed a positive effect of NJE on increasing insulin sensitivity. The homeostatic index of insulin resistance was significantly lower in NJE than in diabetic control group mice. NJE markedly lowered the plasma lipid concentration compared to diabetic control group mice. In the skeletal muscle, the expression of phosphorylated AMP-activated protein kinase, pAkt substrate of 160\u2009kDa, and plasma membrane glucose transporter type 4 increased more in NJE compared to diabetic control group mice. NJE also decreased the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase in the liver. These findings demonstrate that NJE alleviates hyperglycemia by improving insulin sensitivity and inhibiting gluconeogenesis in the liver.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2017.4015","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T14:54:15Z","timestamp":1522335255000},"page":"324-331","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Nardostachys jatamansi DC<\/i>\n                    Extract Alleviates Insulin Resistance and Regulates Glucose Metabolism in C57BL\/KsJ-\n                    <i>db\/db<\/i>\n                    Mice Through the AMP-Activated Protein Kinase Signaling Pathway"],"prefix":"10.1177","volume":"21","author":[{"given":"Han-Nwi","family":"You","sequence":"first","affiliation":[{"name":"Pusan National University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"Silla University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Yeoun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Korea Bio Medical Science Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Sook","family":"Han","sequence":"additional","affiliation":[{"name":"Pusan National University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,4,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2009.10.007"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00037"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18588"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diaspect.20.3.159"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960091"},{"key":"e_1_3_3_7_2","first-page":"99","volume-title":"National Institute of Science Communication","author":"Chatterji A","year":"1997","unstructured":"Chatterji A, , Prakashi SC: The treatise on Indian medicinal plants. In: National Institute of Science Communication, Vol. 5. New Delhi, 1997, pp. 99\u2013100."},{"key":"e_1_3_3_8_2","first-page":"1","article-title":"Nardostachys jatamansi: A chemical, pharmacological and clinical appraisal","volume":"51","author":"Arora RB","year":"1965","unstructured":"Arora RB: Nardostachys jatamansi: A chemical, pharmacological and clinical appraisal. Spec Rep Ser Indian Counc Med Res, 1965; 51:1\u2013117.","journal-title":"Spec Rep Ser Indian Counc Med Res"},{"key":"e_1_3_3_9_2","first-page":"93","article-title":"Stress modulating antioxidant effect of Nardostachys jatamansi","volume":"46","author":"Lyle N","year":"2009","unstructured":"Lyle N, , Bhattacharyya D, , Sur TK, et al.: Stress modulating antioxidant effect of Nardostachys jatamansi. Indian J Biochem Biophys, 2009; 46:93\u201398.","journal-title":"Indian J Biochem Biophys"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.7778\/jpkm.2012.26.2.013"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181bd93ce"},{"key":"e_1_3_3_12_2","first-page":"853","article-title":"Antioxidant and anti-inflammatory effect of Nardostachys chinesis in IFN-\u03b3\/LPS-stimulated peritoneal macrophage","volume":"23","author":"Baek S","year":"2009","unstructured":"Baek S, , Choi JH, , Ko SH, et al.: Antioxidant and anti-inflammatory effect of Nardostachys chinesis in IFN-\u03b3\/LPS-stimulated peritoneal macrophage. Korean J Orient Physiol Pathol, 2009; 23:853\u2013859.","journal-title":"Korean J Orient Physiol Pathol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1087"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.7.6661"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)36843-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00369-4"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80452-0"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)90735-6"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta8130"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.09.005"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.09.010"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020122600107"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1111-y"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010113231503"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-4337.2009.00105.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00645.2007"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666140826115422"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00771.x"},{"key":"e_1_3_3_29_2","first-page":"45","article-title":"Cell fractionation method of the rat liver","volume":"5","author":"Kwak CS","year":"1986","unstructured":"Kwak CS, , Kwak JS: Cell fractionation method of the rat liver. Keimyung Med J, 1986; 5:45\u201353.","journal-title":"Keimyung Med J"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.1.57"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.1.144"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.11.1549"},{"key":"e_1_3_3_33_2","first-page":"737","article-title":"Effect of insulin on glycerol production in obese adolescents","volume":"274","author":"Robinson C","year":"1998","unstructured":"Robinson C, , Tamborlane WV, , Maggs DG, et al.: Effect of insulin on glycerol production in obese adolescents. Am J Physiol, 1998; 274:737\u2013743.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.03.022"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.09.009"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12021"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1139\/H09-047"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/476279"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1066"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300063200"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080595"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2012.06.002"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2014.tb00548.x"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.08.025"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2017.4015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2017.4015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2017.4015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:26:02Z","timestamp":1777645562000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2017.4015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1089\/jmf.2017.4015"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2017.4015","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}