{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:24:00Z","timestamp":1785439440463,"version":"3.56.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n                    The inhibitory effects of taegeuk ginseng extract (TGE) on platelet aggregation and thrombus formation were investigated. The TGE significantly inhibited collagen- and adenosine 5\u2032-diphosphate (ADP)-induced platelet aggregation\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    in a dose-dependent manner. Also oral administration of TGE to rats significantly prevented ADP- and collagen-induced platelet aggregation\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    , but it did not affect the plasma coagulation system. The oral administration of TGE significantly delayed the occlusion of the carotid artery in ferrous chloride-treated rats\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . These results suggest that\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    antithrombotic effect of TGE may be due to its inhibitory activity on platelet aggregation rather than on plasma coagulation.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2017.4145","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T13:55:33Z","timestamp":1538402133000},"page":"1137-1144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Aqueous Extract of Taegeuk Ginseng Inhibits Platelet Aggregation and Thrombus Formation"],"prefix":"10.1177","volume":"21","author":[{"given":"Jaeho","family":"Do","sequence":"first","affiliation":[{"name":"Korea Ginseng MFG Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungwon","family":"Gwak","sequence":"additional","affiliation":[{"name":"Korea Ginseng MFG Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Jin","family":"Rho","sequence":"additional","affiliation":[{"name":"Korea Ginseng MFG Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangseung","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea Ginseng MFG Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Irfan","sequence":"additional","affiliation":[{"name":"Kyungpook National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Hee","family":"Rhee","sequence":"additional","affiliation":[{"name":"Kyungpook National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Chung","family":"Kim","sequence":"additional","affiliation":[{"name":"Chungwoon University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02973912"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13361"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.02.001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00212-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02858168"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000076383"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.1142"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2014.03.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3180cab12e"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.05.008"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb01767.x"},{"key":"e_1_3_3_13_2","first-page":"184","article-title":"In vitro and in vivo effect of ginseng saponins, major components of Korean red ginseng on human platelet aggregation and arachidonic acid metabolism","volume":"5","author":"Yamamoto K","year":"1988","unstructured":"Yamamoto K, , Hirai A, , Tamura Y, , Yoshida S: In vitro and in vivo effect of ginseng saponins, major components of Korean red ginseng on human platelet aggregation and arachidonic acid metabolism. J Tradit Med, 1988; 5:184\u2013190.","journal-title":"J Tradit Med"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.21.79"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-012-0141-y"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2006.00033.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2012.03208.x"},{"key":"e_1_3_3_18_2","first-page":"77","article-title":"Effects of black ginseng (9 times\u2013steaming ginseng) on hypoglycemic action and changes in the composition of ginsenosides on the steaming process","volume":"41","author":"Kim SN","year":"2009","unstructured":"Kim SN, , Kang SJ: Effects of black ginseng (9 times\u2013steaming ginseng) on hypoglycemic action and changes in the composition of ginsenosides on the steaming process. Korean J Food Sci Technol, 2009; 41:77\u201381.","journal-title":"Korean J Food Sci Technol"},{"key":"e_1_3_3_19_2","first-page":"561","article-title":"Determination of 11 ginsenosides in black ginseng developed from Panax ginseng by high performance liquid chromatography","volume":"18","author":"Sun BS","year":"2009","unstructured":"Sun BS, , Gu LJ, , Fang ZM, , Wang CY, , Wang Z, , Sung CK: Determination of 11 ginsenosides in black ginseng developed from Panax ginseng by high performance liquid chromatography. Food Sci Biotechnol, 2009; 18:561\u2013564.","journal-title":"Food Sci Biotechnol"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.5142\/JGR.2005.29.1.001"},{"key":"e_1_3_3_21_2","first-page":"369","article-title":"Water extracts of cultured mountain ginseng stimulate immune cells and inhibit cancer cell proliferation","volume":"15","author":"Oh CH","year":"2006","unstructured":"Oh CH, , Kang PS, , Kim JW, , Kwon J, , Oh SH: Water extracts of cultured mountain ginseng stimulate immune cells and inhibit cancer cell proliferation. Food Sci Biotechnol, 2006; 15:369\u2013373.","journal-title":"Food Sci Biotechnol"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.5142\/jgr.2010.34.3.192"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.5142\/jgr.2010.34.4.355"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X99000288"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(95)01317-2"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/92.1.61"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2004.12.001"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2621.2003.00688.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01967.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075548"},{"key":"e_1_3_3_31_2","first-page":"188","article-title":"Changes in effective components of ginseng by puffing","volume":"51","author":"Kim JH","year":"2008","unstructured":"Kim JH, , Ahn SC, , Choi SW, , Hur NY, , Kim BY, , Baik MY: Changes in effective components of ginseng by puffing. J Appl Biol Chem, 2008; 51:188\u2013193.","journal-title":"J Appl Biol Chem"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2010.09.013"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.5142\/JGR.2007.31.4.222"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.02.005"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283406323"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(92)90057-X"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2017.06.002"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980000000550"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16065268"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.11.027"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2011.0591"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801082"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2017.4145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2017.4145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2017.4145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:26:25Z","timestamp":1777645585000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2017.4145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1089\/jmf.2017.4145"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2017.4145","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}