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Its treatment remains a challenge as therapeutic options are limited, unsatisfactory, and elusive. Thus, safety and efficacy of DigeZyme\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">\u00ae<\/jats:italic>\n                    <\/jats:sup>\n                    , a proprietary multienzyme complex (MEC), was evaluated as a dietary supplement in FD patients. In this randomized, double-blind, placebo-controlled, parallel-group study, 40 patients were randomly assigned (1:1 ratio) to receive either MEC (50\u2009mg, TID;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200920) or placebo (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200920) for 60 days. Reports of adverse or serious adverse events (AEs), abnormal results of vital signs, abnormal findings during physical examination, and abnormal laboratory investigations were monitored closely. Efficacy measures were change in Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), Nepean Dyspepsia Index-Short Form (NDI-SF), Visual Analog Scale (VAS), Clinical Global Impression Severity Rating Scale (CGI-S), and Glasgow Dyspepsia Severity Score (GDSS) at baseline and follow-up visits on day 15, 30, and 60. Supplementation with MEC was associated with statistically significant differences (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    value ranging from .0401 to .0033) in all efficacy parameters compared with placebo. The between-group comparison also revealed that MEC supplement had a significantly greater effect (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001) versus placebo. No investigation product-related AEs were reported. There were no clinically significant abnormalities in physical findings and no statistically significant changes in biochemical and hematological parameters, vital signs, body weight, and body mass index observed between the two groups at baseline and follow-up visits. MEC supplementation represents an effective and safe alternative to manage dyspepsia symptoms in FD patients.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2017.4172","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T01:53:10Z","timestamp":1535593990000},"page":"1120-1128","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of the Safety and Efficacy of a Multienzyme Complex in Patients with Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study"],"prefix":"10.1177","volume":"21","author":[{"given":"Muhammed","family":"Majeed","sequence":"first","affiliation":[{"name":"Sami Labs Limited","place":["India"]},{"name":"Sabinsa Corporation"},{"name":"Sabinsa Corporation"},{"name":"ClinWorld Private Limited","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaheen","family":"Majeed","sequence":"additional","affiliation":[{"name":"Sami Labs Limited","place":["India"]},{"name":"Sabinsa Corporation"},{"name":"Sabinsa Corporation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyanam","family":"Nagabhushanam","sequence":"additional","affiliation":[{"name":"Sabinsa Corporation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivakumar","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Sami Labs Limited","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag","family":"Pande","sequence":"additional","affiliation":[{"name":"Sabinsa Corporation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Paschapur","sequence":"additional","affiliation":[{"name":"Sami Labs Limited","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furqan","family":"Ali","sequence":"additional","affiliation":[{"name":"Sami Labs Limited","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i17.2656"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1501505"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052639"},{"key":"e_1_3_3_5_2","unstructured":"Non-ulcer dyspepsia: www.ddc.musc.edu\/public\/diseases\/stomach-duodenum\/non-ulcer-dyspepsia.html (accessed June2016)."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i17.2661"},{"key":"e_1_3_3_7_2","unstructured":"Rome III diagnostic criteria for functional gastrointestinal disorders: www.romecriteria.org\/assets\/pdf\/19_RomeIII_apA_885-898.pdf (accessed July2016)."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.091"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.25"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12089.1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12094"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90451-8"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.026"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-5-200103060-00008"},{"key":"e_1_3_3_15_2","first-page":"145","article-title":"Helicobacter pylori and dyspepsia","volume":"72","author":"Talley NJ","year":"1999","unstructured":"Talley NJ: Helicobacter pylori and dyspepsia. 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