{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:37:52Z","timestamp":1791549472916,"version":"4.3.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Campomanesia adamantium<\/jats:italic>\n                    , a native species of the Brazilian Cerrado, is characterized as a natural source of phenolic compounds and has known potential anticancer activities. This study aimed to evaluate the chemical profile of dichloromethane extracts of pulp (DEGPU) and peel (DEGPE) from the fruits of\n                    <jats:italic toggle=\"yes\">C. adamantium<\/jats:italic>\n                    and to identify compounds with antiproliferative effects\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    against melanoma cells by sulforhodamine B (SRB) assay, apoptosis induction assay, caspase-3 activation assay, nitric oxide (NO) release in coculture of B16-F10 cells and murine peritoneal macrophages. The chemical profiles of DEGPU and DEGPE were analyzed by high performance liquid chromatography coupled to diode array detector and mass spectrometer using the electrospray ionization interface (HPLC-DAD-ESI-MS\/MS). Thirteen compounds were identified in both extracts and the chromatographic study of the most active extract in SRB assay DEGPU (GI\n                    <jats:sub>50<\/jats:sub>\n                    of 16.17\u2009\n                    <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                    g\/mL) resulted in the isolation of seven compounds. The isolated compound dimethylchalcone (DMC) had the highest antiproliferative activity against B16-F10 with a GI\n                    <jats:sub>50<\/jats:sub>\n                    of 7.11\u2009\n                    <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                    g\/mL. DEGPU extract activated caspase-3 in 29% of cells at 25\u2009\n                    <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                    g\/mL and caused a 50% decrease in NO release in coculture. DEGPU can be characterized as a source of bioactive compounds such as DMC, as seen from its antiproliferative effect\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    by inducing B16-F10 cells to undergo apoptosis, essential feature in the search for new anticancer drugs.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2018.0001","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T14:46:25Z","timestamp":1525185985000},"page":"1024-1034","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Antiproliferative Activity of Extracts of\n                    <i>Campomanesia adamantium<\/i>\n                    (Cambess.) O. Berg and Isolated Compound Dimethylchalcone Against B16-F10 Murine Melanoma"],"prefix":"10.1177","volume":"21","author":[{"given":"Magalli C.B.","family":"Lima e Silva","sequence":"first","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Bogo","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A.F.","family":"Alexandrino","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata T.","family":"Perdomo","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia de O.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela R.","family":"do Prado","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda R.","family":"Garcez","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica C.T.","family":"Kadri","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalita V.N.","family":"Ximenes","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita de Cassia A.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulana C.","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L\u00edgia R.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"422","volume-title":"Cerrado: Ecologia e Flora","author":"Mendon\u00e7a RC","year":"2008","unstructured":"Mendon\u00e7a RC, , Felfili JM, , Walter BMT, , Silva Junior MC, , Rezende AV, , Filgueiras TS, , Nogueira PE, , Fagg CW: Flora Vascular do Bioma Cerrado: checklist com 12,356 esp\u00e9cies. 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