{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:24:16Z","timestamp":1782948256622,"version":"3.54.5"},"reference-count":35,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Melissa officinalis<\/jats:italic>\n                    L. (lemon balm) has been used for decades with symptomatic benefits in patients with digestive disorders. However, very little is known on the effects of\n                    <jats:italic toggle=\"yes\">M. officinalis<\/jats:italic>\n                    on the gastrointestinal (GI) tract. In this study, the basal and spasmolytic properties of a hydroethanolic leaf extract (HLE) of\n                    <jats:italic toggle=\"yes\">M. officinalis<\/jats:italic>\n                    were assessed\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    on different segments of the GI tract of mice after phytochemical characterization of the extract.\n                    <jats:italic toggle=\"yes\">M. officinalis<\/jats:italic>\n                    HLE had site- and dose-dependent effects on the contractile activity of the GI tract, the motility response being impacted in the jejunum and ileum but not in the antrum and colon. The observed effects could be caused by the phenolic compounds (mainly rosmarinic acid) detected in the extract.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2018.0154","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T15:04:53Z","timestamp":1555427093000},"page":"653-662","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of\n                    <i>Melissa officinalis<\/i>\n                    L. on Intestinal Motility: An\n                    <i>Ex Vivo<\/i>\n                    Study"],"prefix":"10.1177","volume":"22","author":[{"given":"Philippe","family":"Aubert","sequence":"first","affiliation":[{"name":"Bretagne Loire University, Nantes University, INSERM 1235, IMAD, The Enteric Nervous System in Gut and Brain Disorders, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Guinobert","sequence":"additional","affiliation":[{"name":"PiLeJe Group, Paris, France."},{"name":"Naturop\u00f4le, Saint-Bonnet de Rochefort, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Blondeau","sequence":"additional","affiliation":[{"name":"PiLeJe Group, Paris, France."},{"name":"Naturop\u00f4le, Saint-Bonnet de Rochefort, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Bardot","sequence":"additional","affiliation":[{"name":"PiLeJe Group, Paris, France."},{"name":"Naturop\u00f4le, Saint-Bonnet de Rochefort, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Ripoche","sequence":"additional","affiliation":[{"name":"Clermont Auvergne University, CNRS, SIGMA Clermont, Clermont-Ferrand Chemistry Institute, Clermont Ferrand, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chalard","sequence":"additional","affiliation":[{"name":"Clermont Auvergne University, CNRS, SIGMA Clermont, Clermont-Ferrand Chemistry Institute, Clermont Ferrand, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Neunlist","sequence":"additional","affiliation":[{"name":"Bretagne Loire University, Nantes University, INSERM 1235, IMAD, The Enteric Nervous System in Gut and Brain Disorders, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300230"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1668"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.05.010"},{"key":"e_1_3_3_5_2","unstructured":"European Medicine Agency: Community Herbal Monograph on Melissa officinalis L. 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