{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:15:59Z","timestamp":1790716559168,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n                    Neuropathic pain (NP) is associated with chronic hyperglycemia and emotional disorders such as depression in diabetic patients, complicating the course of treatment. Drugs currently used to treat NP have undesirable side effects, so research on other natural sources has been required.\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -caryophyllene (BCP), a natural sesquiterpene found in some food condiments and considered an agonist to cannabinoid receptor type 2, could have potential therapeutic effects to treat conditions such as NP and emotional disorders. For this reason, we assessed whether BCP modulates nociception, anxiety, and depressive-like behavior in streptozotocin (STZ)-induced experimental diabetic BALB\/c female mice. BCP was orally chronic administrated (10\u2009mg\/kg\/60\u2009\n                    <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                    L). Pain developed with STZ was evaluated with von Frey filament test, SMALGO\n                    <jats:sup>\u00ae<\/jats:sup>\n                    , and hot plate test. Anxiety and depression-like behavior were assessed by marbles test, forced swim test, and tail suspension test. BCP significantly reduced glycemia in experimental diabetic mice. The pain was also mitigated by BCP administration. Depression-like behavior assessed with tail suspension test was attenuated with orally chronic BCP administration. Substance P and cytokines such as interleukin-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    (IL-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    ), tumor necrosis factor\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    (TNF-\u03b1), and interleukin-6 (IL-6) were also attenuated with BCP administration. NP was positively correlated with substance P and IL-6 and IL-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    release. Our data using an orally chronic BCP administration in the STZ challenged mice to suggest that glycemia, diabetes-related NP, and depressive-like behavior could be prevented\/reduced by dietary BCP.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2018.0157","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T11:46:34Z","timestamp":1552477594000},"page":"460-468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":80,"title":["<i>\u03b2<\/i>\n                    -Caryophyllene, a Natural Sesquiterpene, Attenuates Neuropathic Pain and Depressive-Like Behavior in Experimental Diabetic Mice"],"prefix":"10.1177","volume":"22","author":[{"given":"Dalia Samanta","family":"Aguilar-\u00c1vila","sequence":"first","affiliation":[{"name":"Laboratory of Research and Pharmaceutical Development, University of Guadalajara, Guadalajara, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Eduardo","family":"Flores-Soto","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Neurobiology, Mexican Social Security Institute (IMSS), Guadalajara, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Tapia-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratory of Research and Pharmaceutical Development, University of Guadalajara, Guadalajara, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Alonso","family":"Pastor-Zarandona","sequence":"additional","affiliation":[{"name":"Laboratory of Research and Pharmaceutical Development, University of Guadalajara, Guadalajara, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo Ivette","family":"L\u00f3pez-Roa","sequence":"additional","affiliation":[{"name":"Laboratory of Research and Pharmaceutical Development, University of Guadalajara, Guadalajara, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Viveros-Paredes","sequence":"additional","affiliation":[{"name":"Laboratory of Research and Pharmaceutical Development, University of Guadalajara, Guadalajara, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.06.020"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.12.004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4271-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.05.008"},{"key":"e_1_3_3_6_2","first-page":"394","article-title":"The effect of spinally administered win 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats","volume":"19","author":"Jahanabadi S","year":"2016","unstructured":"Jahanabadi S, , Hadian MR, , Shamsaee J, et al.: The effect of spinally administered win 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats. 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