{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:45:25Z","timestamp":1788295525114,"version":"build-2803163510"},"reference-count":55,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    The flavonoid myricitrin exhibits various pharmacological and physiological effects. However, studies on the effects of myricitrin on obesity are limited. We hypothesized that dietary myricitrin would attenuate the adiposity and metabolic dysfunction that occur in obesity. To test this hypothesis, mice were randomly fed a high-fat diet (HFD) or HFD supplemented with myricitrin for 16 weeks. Myricitrin significantly reduced white adipose tissue (WAT) mass, adipocyte size, and plasma leptin levels, and also attenuated dyslipidemia. These changes appeared to result from increased energy expenditure and activation of the carnitine acyltransferase (CPT) and\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -oxidation in WAT. Expressions of the proinflammatory genes\n                    <jats:italic toggle=\"yes\">NF-\u03baB<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">TLR2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">MCP1<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">TNF-\u03b1<\/jats:italic>\n                    were also lower in the WAT of myricitrin-supplemented mice. Moreover, myricitrin markedly reduced hepatic triglyceride accumulation and plasma aspartate transaminase levels by increasing CPT activity and reducing fatty acid synthase activity in the liver. Myricitrin-supplemented mice also showed improved glucose tolerance, insulin sensitivity, and decreased hyperinsulinemia, along with decreased levels of circulating resistin. In conclusion, long-term consumption of a myricitrin-supplemented diet may effectively protect against HFD-induced obesity and related metabolic disorders.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2018.4341","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T10:27:02Z","timestamp":1569320822000},"page":"1151-1158","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Supplementation of the Flavonoid Myricitrin Attenuates the Adverse Metabolic Effects of Long-Term Consumption of a High-Fat Diet in Mice"],"prefix":"10.1177","volume":"22","author":[{"given":"Young-Je","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition, Kyungpook National University, Daegu, Korea."},{"name":"Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ryong","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pukyong National University, Busan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Tae","family":"Woo","sequence":"additional","affiliation":[{"name":"Okinawa Research Center Co. Ltd., Okinawa Health Biotechnology Research and Development Center, Uruma, Japan."},{"name":"Department of Environmental Biology, College of Bioscience and Biotechnology, Chubu University, Kasugai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Kyungpook National University, Daegu, Korea."},{"name":"Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngji","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Kyungpook National University, Daegu, Korea."},{"name":"Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Sook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Kyungpook National University, Daegu, Korea."},{"name":"Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Un Ju","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pukyong National University, Busan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-014-0243-x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.012"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15046184"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu5020498"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786411003774320"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep44239"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6093783"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.01.030"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.04.015"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16108305"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.12.047"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/787152"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2014.8.5.544"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1600074"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8120799"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.02.006"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.08.091"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.3995"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)36843-7"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(75)35136-7"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)43946-X"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(81)72021-4"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.09.017"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.25.050304.092532"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp7001363"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389200216666150206123719"},{"key":"e_1_3_4_31_2","first-page":"516","article-title":"Quantitative determination of myricetin in rat plasma by ultraperformance liquid chromatography tandem mass spectrometry and its absolute bioavailability","volume":"64","author":"Dang Y","year":"2014","unstructured":"Dang Y, , Lin G, , Xie Y, , Duan J, , Ma P, , Li G, , Ji G: Quantitative determination of myricetin in rat plasma by ultraperformance liquid chromatography tandem mass spectrometry and its absolute bioavailability. 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