{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:41:29Z","timestamp":1777909289482,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    Naringin and its aglycone, naringenin, occur naturally in our regular diet and traditional Chinese medicines. This study aimed to detect an effective therapeutic approach for cough variant asthma (CVA) through evaluating the relaxant effect of these two bioactive herbal monomers as antitussive and antiasthmatic on rat tracheal smooth muscle. The relaxant effect was determined by measuring muscular tension with a mechanical recording system in rat tracheal rings. Cytosolic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    concentration was measured using a confocal imaging system in primary cultured tracheal smooth muscle cells. In rat tracheal rings, addition of both naringin and naringenin could concentration dependently relax carbachol (CCh)-evoked tonic contraction. This epithelium-independent relaxation could be suppressed by BaCl\n                    <jats:sub>2<\/jats:sub>\n                    , tetraethylammonium, and iberiotoxin (IbTX), but not by glibenclamide. After stimulating primary cultured tracheal smooth muscle cells by CCh or high KCl, the intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    increase could be inhibited by both naringin and naringenin, respectively. This reaction was also suppressed by IbTX. These results demonstrate that both naringin and naringenin can relax tracheal smooth muscle through opening big conductance Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -activated K\n                    <jats:sup>+<\/jats:sup>\n                    channel, which mediates plasma membrane hyperpolarization and reduces Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx. Our data indicate a potentially effective therapeutic approach of naringin and naringenin for CVA.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2018.4364","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T11:34:56Z","timestamp":1561980896000},"page":"963-970","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BK\n                    <sub>Ca<\/sub>\n                    Activation"],"prefix":"10.1177","volume":"22","author":[{"given":"Rui","family":"Shi","sequence":"first","affiliation":[{"name":"Guangdong Engineering and Technology Research Center for Quality and Efficacy Reevaluation of Postmarket Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China."},{"name":"State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China."},{"name":"School of Life Sciences, Sun Yat-sen University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Wen","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Sun Yat-sen University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Ting","family":"Xiao","sequence":"additional","affiliation":[{"name":"Guangdong Engineering and Technology Research Center for Quality and Efficacy Reevaluation of Postmarket Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China."},{"name":"State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China."},{"name":"School of Life Sciences, Sun Yat-sen University, Guangzhou, 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