{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:41:31Z","timestamp":1777909291327,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n                    Alzheimer's disease accounts for the majority of dementia and shows hallmarks such as sequential cognitive dysfunction and abnormal behavior.\n                    <jats:italic toggle=\"yes\">Dendropanax morbifera<\/jats:italic>\n                    (DM) has traditionally been used to treat a variety of diseases in East Asia. The aim of this study was to assess the therapeutic effects of DM on brain neuron damage and on cognitive deficit in neuronal cell induced by A\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    <jats:sub>1\u201342<\/jats:sub>\n                    in mice. Treatment with DM reduced the levels of intracellular reactive oxygen species and protected against the death of neuronal cells induced by A\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    <jats:sub>1\u201342<\/jats:sub>\n                    peptide. In addition, it was also found that pretreatment with DM decreased cognitive damage induced by A\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    peptide via enhancing the cholinergic system and antioxidant defense system in mice. Furthermore, the study verified that the change in the expression of both cyclic-adenosine monophosphate response element binding protein and of brain-derived neurotrophic factor in the hippocampus in A\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    peptide-treated mice was significantly ameliorated after treatment with DM. Accordingly, these results suggest that pretreatment with DM defends against oxidative stress and cognitive impairment caused by A\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    peptide.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2018.4375","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T17:10:02Z","timestamp":1556039402000},"page":"587-593","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Ameliorative Effects of\n                    <i>Dendropanax morbifera<\/i>\n                    on Cognitive Impairment Via Enhancing Cholinergic Functions and Brain-Derived Neurotrophic Factor Expression in\n                    <i>\u03b2<\/i>\n                    -Amyloid-Induced Mice"],"prefix":"10.1177","volume":"22","author":[{"given":"Mi-Jeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Brain Korea 21 Project for Medical Sciences, Severance Medical Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Brain Korea 21 Project for Medical Sciences, Severance Medical Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Brain Korea 21 Project for Medical Sciences, Severance Medical Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjae","family":"Kim","sequence":"additional","affiliation":[{"name":"J-well Biofarm Research Institute, Jeju-si, Jeju-do, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Biotechnology, Korea University, Sejong, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woojin","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Chonnam National University, Gwangju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Geun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Brain Korea 21 Project for Medical Sciences, Severance Medical Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35040009"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn940"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00215.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90239-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68052061.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8958-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.04.014"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12681"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.06.042"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.09.019"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000368466"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.11.002"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/1811199a0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.07.024"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.04.012"},{"key":"e_1_3_3_17_2","first-page":"256","article-title":"Effects of amyloid-\u03b2-(25\u201335) on passive avoidance, radial-arm maze learning and choline acetyltransferase activity in the rat","volume":"421","author":"Yamaguchi Y","year":"2001","unstructured":"Yamaguchi Y, , Kawashima S: Effects of amyloid-\u03b2-(25\u201335) on passive avoidance, radial-arm maze learning and choline acetyltransferase activity in the rat. 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