{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:41:32Z","timestamp":1777909292818,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Echinodorus grandiflorus<\/jats:italic>\n                    is an important medicinal plant species that is native to South America. Despite extensive popular usage as a hypolipidemic drug, its effects as an atheroprotective agent remain unknown. The aim of this study was to evaluate the effects of an ethanol-soluble fraction that was obtained from\n                    <jats:italic toggle=\"yes\">E. grandiflorus<\/jats:italic>\n                    (ESEG) leaves against the development of atherosclerosis in rabbits. Male rabbits received a diet that was supplemented with 1% cholesterol (cholesterol-rich diet [CRD]) for 60 days. After 30 days of the CRD, the animals were divided into five groups (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20096) and treated with ESEG (10, 30, and 100\u2009mg\/kg), simvastatin (2.5\u2009mg\/kg), or vehicle once daily for 30 days. The negative control group was fed a cholesterol-free diet and treated orally with vehicle. At the end of 60 days, serum lipids, oxidized low-density lipoprotein, thiobarbituric acid reactive substances, nitrotyrosine, and serum interleukin 1 beta (IL-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    ), IL-6, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels were determined. Samples from the aortic arch and thoracic segment were also collected to investigate the tissue antioxidant defense system and perform histopathological analysis. Oral ESEG administration significantly reduced serum lipid levels in CRD-fed rabbits. This treatment also modulated the arterial antioxidant defense system by reducing lipid and protein oxidation. Similarly, serum IL-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    , IL-6, sICAM-1, and sVCAM-1 levels significantly decreased, accompanied by a reduction of atherosclerotic lesions in all arterial branches. These findings suggest that ESEG may be a new herbal medicine that can be directly applied for the treatment and prevention of atherosclerotic disease.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2019.0017","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T09:54:47Z","timestamp":1561456487000},"page":"919-927","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Antiatherosclerotic Properties of\n                    <i>Echinodorus grandiflorus<\/i>\n                    (Cham. &amp; Schltdl.) Micheli: From Antioxidant and Lipid-Lowering Effects to an Anti-Inflammatory Role"],"prefix":"10.1177","volume":"22","author":[{"given":"Francielly Mour\u00e3o","family":"Gasparotto","sequence":"first","affiliation":[{"name":"Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhanany Alan Calloi","family":"Palozi","sequence":"additional","affiliation":[{"name":"Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Henrique Francisconi","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University (UNIPAR), Umuarama, Parana\u00b4, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoline Bach","family":"Pauli","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University (UNIPAR), Umuarama, Parana\u00b4, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Donadel","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University (UNIPAR), Umuarama, Parana\u00b4, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Henrique Lopes Botelho","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University (UNIPAR), Umuarama, Parana\u00b4, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Caroline","family":"Nunes","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University (UNIPAR), Umuarama, Parana\u00b4, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francislaine Aparecida dos Reis","family":"L\u00edvero","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University (UNIPAR), Umuarama, Parana\u00b4, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauro Mera","family":"de Souza","sequence":"additional","affiliation":[{"name":"Institute of Research Pel\u00e9 Pequeno Pr\u00edncipe, Pequeno Pr\u00edncipe Faculty, Curitiba, Paran\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emerson Luiz Botelho","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University (UNIPAR), Umuarama, Parana\u00b4, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e2ndida Aparecida Leite","family":"Kassuya","sequence":"additional","affiliation":[{"name":"Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arquimedes","family":"Gasparotto Junior","sequence":"additional","affiliation":[{"name":"Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1074248413504994"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2015.05.010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.03.005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3444"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2017.03.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/2156587214568457"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/480258"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Bolson M Hefler SR Chaves EID Gasparotto Junior A Cardozo Junior EL: Ethno-medicinal study of plants used for treatment of human ailments with residents of the surrounding region of forest fragments of Paran\u00e1 Brazil: J Ethnopharmacol 2015;161:1\u201310.","DOI":"10.1016\/j.jep.2014.11.045"},{"key":"e_1_3_2_10_2","first-page":"243","volume-title":"Medicinal Plants: Classification, Biosynthesis and Pharmacology","author":"Brugiolo SSS","year":"2009","unstructured":"Brugiolo SSS, , Borges LV, , Pimenta DS, , Brugioro ASS, , Peters VM, , Guerra MO: Ethnobotany and experimental pharmacology of Echinodorus grandiflorus (chap\u00e9u-de-couro). 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