{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:41:40Z","timestamp":1777909300498,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    Air-dried leaves of a\n                    <jats:italic toggle=\"yes\">Musa<\/jats:italic>\n                    spp. AAB, cv. \u201cManzano\u201d plant, known as\n                    <jats:italic toggle=\"yes\">Ja'as<\/jats:italic>\n                    in the Maya culture, were sequentially extracted with hexane, ethyl acetate, and methanol; the resulting extracts were investigated for their antimycobacterial activity against susceptible and drug-resistant strains of\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    (MTB) using the Microplate Alamar Blue Assay. Both the n-hexane extract (HE) and ethyl acetate extract (EE) showed potent activity against both strains of MTB, with the EE exhibiting the strongest activity and a Minimum Inhibitory Concentration of 12.5 and 6.25\u2009\u03bcg\/mL against susceptible and drug-resistant strains, respectively. Both extracts also demonstrated a mycobactericidal effect and a very good selectivity index when tested for cytotoxic activity on Vero monkey kidney cells, using the Sulforhodamine B assay. Our results demonstrate the efficiency and selectivity of\n                    <jats:italic toggle=\"yes\">Musa<\/jats:italic>\n                    spp. AAB, cv. \u201cManzano\u201d against MTB strains and support its traditional use as remedy against tuberculosis in Maya traditional medicine.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2019.0075","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T09:48:45Z","timestamp":1562147325000},"page":"1183-1185","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Bactericidal Effect of the Leaf Extract from\n                    <i>Musa<\/i>\n                    spp. (AAB Group, Silk Subgroup), cv. \u201cManzano\u201d Against Multidrug-Resistant\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1177","volume":"22","author":[{"given":"Gloria Mar\u00eda","family":"Molina-Salinas","sequence":"first","affiliation":[{"name":"Unit of Medical Research Yucatan, Medical Unit of High Specialty, Specialty Hospital 1, M\u00e9rida, Yucatan, Mexican Social Security Institute, IMSS, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s Humberto","family":"Uc-Cach\u00f3n","sequence":"additional","affiliation":[{"name":"Unit of Medical Research Yucatan, Medical Unit of High Specialty, Specialty Hospital 1, M\u00e9rida, Yucatan, Mexican Social Security Institute, IMSS, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Manuel","family":"Pe\u00f1a-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Plant Biotechnology Unit, Yucatan Center for Scientific Research, M\u00e9rida, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel de Jes\u00fas","family":"Dzul-Beh","sequence":"additional","affiliation":[{"name":"Unit of Medical Research Yucatan, Medical Unit of High Specialty, Specialty Hospital 1, M\u00e9rida, Yucatan, Mexican Social Security Institute, IMSS, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Mar\u00eda","family":"Escobedo Grac\u00eda-Medrano","sequence":"additional","affiliation":[{"name":"Plant Molecular Biology and Biochemistry Unit, Yucatan Center for Scientific Research, M\u00e9rida, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Global tuberculosis report. World Health Organization Geneva 2018. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/274453\/9789241565646-eng.pdf?ua=1 (accessed March2019)."},{"key":"e_1_3_3_3_2","first-page":"307","article-title":"Letter to editor. The totally drug resistant tuberculosis (TDR-TB)","volume":"6","author":"Velayati AA","year":"2013","unstructured":"Velayati AA, , Farnia P, , Masjedi MR: Letter to editor. The totally drug resistant tuberculosis (TDR-TB). Int J Clin Exp Med, 2013; 6:307\u2013309.","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_3_4_2","first-page":"22","article-title":"Development of new antituberculosis agents","volume":"7","author":"del Olmo-Fern\u00e1ndez E","year":"2005","unstructured":"del Olmo-Fern\u00e1ndez E, , L\u00f3pez-P\u00e9rez JL, , San Feliciano A, , Garc\u00eda AE: Development of new antituberculosis agents. Enf Emerg, 2005; 7:22\u201333.","journal-title":"Enf Emerg"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2018.368-372"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2015.08.002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.02.010"},{"key":"e_1_3_3_8_2","first-page":"51","article-title":"Traditional and medicinal uses of banana","volume":"1","author":"Kumar KPS","year":"2012","unstructured":"Kumar KPS, , Bhowmik D, , Duraivel S, , Umadevi M: Traditional and medicinal uses of banana. J Pharmacogn Phytochem, 2012; 1:51\u201363.","journal-title":"J Pharmacogn Phytochem"},{"key":"e_1_3_3_9_2","first-page":"14","article-title":"Musa paradisiaca L. and Musa sapientum L.: A phytochemical and pharmacological review","volume":"01","author":"Imam MZ","year":"2011","unstructured":"Imam MZ, , Akter S: Musa paradisiaca L. and Musa sapientum L.: A phytochemical and pharmacological review. J Appl Pharm Sci, 2011; 01:14\u201320.","journal-title":"J Appl Pharm Sci"},{"key":"e_1_3_3_10_2","first-page":"66","article-title":"Musa\u2009\u00d7\u2009paradisiaca L. (banana): hexane leaf- and ethyl acetatrhizome-extracts are active on Mycobaterium tuberculosis resistant to first-line antitubercular medications","volume":"47","author":"Molina-Salinas GM","year":"2016","unstructured":"Molina-Salinas GM, , Mart\u00ednez-Rodr\u00edguez HG, , Ortega-Garc\u00eda JL, , Mart\u00ednez-Mart\u00ednez YB, , Garza-Trevi\u00f1o EN, , Said-Fern\u00e1ndez S: Musa\u2009\u00d7\u2009paradisiaca L. (banana): hexane leaf- and ethyl acetatrhizome-extracts are active on Mycobaterium tuberculosis resistant to first-line antitubercular medications. Rev Mex Cienc Farm, 2016; 47:66\u201373.","journal-title":"Rev Mex Cienc Farm"},{"key":"e_1_3_3_11_2","first-page":"149","volume-title":"Messages from the Gods: A guide to the Useful Plants of Belize","author":"Balick MJ","year":"2015","unstructured":"Balick MJ, , Arvigo R: Plants of Belize and their uses in ancient and contemporary times and ethnobotanical compendium. In: Messages from the Gods: A guide to the Useful Plants of Belize, Oxford University Press, New York, 2015, pp. 149\u2013150."},{"key":"e_1_3_3_12_2","unstructured":"Manzanilla-Interian AM: Medicinal plants in Oxkutzcab a reencounter with our Maya roots. Universidad Aut\u00f3noma Chapingo M\u00e9xico 2009 p. 49."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1300\/J044v04n01_07"},{"key":"e_1_3_3_14_2","first-page":"5","volume-title":"El libro del Judio","author":"Barrera A","year":"1983","unstructured":"Barrera A, , Barrera-Vasquez A: \u201cMedicina domestica\u201d. In: El libro del Judio, Compa\u00f1ia editorial Continental, S.A de C.V., M\u00e9xico D.F., 1983, p. 5."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.04.010"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.13.1107"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-6-39"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1250027"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-2057-9"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(03)00144-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(13)60148-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.12.029"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-291"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2019.0075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2019.0075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2019.0075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:27:31Z","timestamp":1777645651000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2019.0075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1089\/jmf.2019.0075"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2019.0075","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}