{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:41:41Z","timestamp":1777909301413,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    Metabolic syndrome is recognized as a proinflammatory condition leading to hepatic steatosis and nonalcoholic steatohepatitis (NASH). We tested the effects of a succulent species\n                    <jats:italic toggle=\"yes\">Hoodia parviflora<\/jats:italic>\n                    N.E. Br., of the\n                    <jats:italic toggle=\"yes\">genus Hoodia sweet<\/jats:italic>\n                    ex Dence, on animal models of NASH and insulin resistance (\n                    <jats:italic toggle=\"yes\">ob\/ob<\/jats:italic>\n                    mouse and the sand rat\n                    <jats:italic toggle=\"yes\">Psammomys obesus<\/jats:italic>\n                    ). IL6 secretion was evaluated by ELISA and hepatic signal transducer and activator of transcription 3 by Western blot. We followed liver enzymes, weight, glucose, hepatic histology, hepatic triglycerides (TGs), and total fat and serum insulin. Oral administration of extracts derived from\n                    <jats:italic toggle=\"yes\">H. parviflora<\/jats:italic>\n                    alleviated the insulin resistance manifested by improved glucose tolerance tests. Treatment alleviated the liver injury noted by a decrease in liver enzyme levels, improved intrahepatic TG content, total hepatic fat, and improved hepatic histology. Similarly, treatment with\n                    <jats:italic toggle=\"yes\">H. parviflora<\/jats:italic>\n                    reduced hepatic inflammation in mice with Concanavalin A-induced hepatitis. These effects were independent of food consumption and weight.\n                    <jats:italic toggle=\"yes\">H. parviflora<\/jats:italic>\n                    was associated with alleviated insulin resistance, hepatic steatosis, and liver injury. The data support its use as a liver protector.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2019.0093","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T16:28:46Z","timestamp":1571675326000},"page":"1189-1198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Oral Administration of\n                    <i>Hoodia parviflora<\/i>\n                    Alleviates Insulin Resistance and Nonalcoholic Steatohepatitis"],"prefix":"10.1177","volume":"22","author":[{"given":"Meir","family":"Mizrahi","sequence":"first","affiliation":[{"name":"Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami","family":"Ben Ya'acov","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomer","family":"Adar","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Levy Sklair","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Gaska","sequence":"additional","affiliation":[{"name":"Goldyne Savad Institute of Gene Therapy, Hebrew University-Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Ilan","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.02.009"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03710.x"},{"key":"e_1_3_1_4_2","first-page":"637","article-title":"Non-alcoholic steatohepatitis and metabolic syndrome","volume":"9","author":"Machado M","year":"2006","unstructured":"Machado M, , Cortez-Pinto H: Non-alcoholic steatohepatitis and metabolic syndrome. 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